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    Pink1 PTEN induced putative kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 68943, updated on 14-Jan-2025

    Summary

    Official Symbol
    Pink1provided by MGI
    Official Full Name
    PTEN induced putative kinase 1provided by MGI
    Primary source
    MGI:MGI:1916193
    See related
    Ensembl:ENSMUSG00000028756 AllianceGenome:MGI:1916193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BRPK; mFLJ00387; 1190006F07Rik
    Summary
    Enables ATP binding activity; magnesium ion binding activity; and protein kinase activity. Involved in several processes, including negative regulation of apoptotic process; protein stabilization; and regulation of gene expression. Acts upstream of or within positive regulation of dopamine secretion; positive regulation of dopaminergic synaptic transmission; and positive regulation of mitochondrial electron transport, NADH to ubiquinone. Located in endoplasmic reticulum and mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study Parkinson's disease 6. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 197.7), heart adult (RPKM 154.1) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Pink1 in Genome Data Viewer
    Location:
    4 D3; 4 70.14 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138040718..138053631, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138313409..138326296, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54278 Neighboring gene kinesin family member 17 Neighboring gene STARR-positive B cell enhancer ABC_E8002 Neighboring gene STARR-positive B cell enhancer ABC_E4692 Neighboring gene STARR-seq mESC enhancer starr_11799 Neighboring gene dolichyl-di-phosphooligosaccharide-protein glycotransferase Neighboring gene STARR-positive B cell enhancer ABC_E10270 Neighboring gene microRNA 7019 Neighboring gene cytidine deaminase Neighboring gene hypothetical protein, MNCb-2457 Neighboring gene family with sequence similarity 43, member B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 45
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding PubMed 
    enables ATP binding  
    enables C3HC4-type RING finger domain binding  
    enables C3HC4-type RING finger domain binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables TORC2 complex binding  
    enables TORC2 complex binding  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables kinase activity PubMed 
    enables kinase activity  
    enables magnesium ion binding PubMed 
    enables magnesium ion binding  
    enables protease binding  
    enables protease binding  
    enables protein binding PubMed 
    enables protein kinase B binding  
    enables protein kinase B binding  
    enables protein kinase activity  
    enables protein serine kinase activity PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding  
    enables ribosomal protein S6 kinase activity  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 45
    Items 1 - 25 of 97
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion  
    involved_in autophagy of mitochondrion  
    involved_in autophagy of mitochondrion  
    acts_upstream_of catecholamine secretion PubMed 
    involved_in cellular response to hydrogen sulfide  
    involved_in cellular response to hydrogen sulfide  
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to hypoxia  
    involved_in cellular response to oxidative stress PubMed 
    involved_in cellular response to oxidative stress  
    involved_in cellular response to toxic substance PubMed 
    involved_in chromatin remodeling  
    acts_upstream_of dopamine secretion PubMed 
    acts_upstream_of establishment of localization in cell PubMed 
    involved_in establishment of protein localization to mitochondrion  
    involved_in establishment of protein localization to mitochondrion  
    involved_in hemopoiesis  
    acts_upstream_of_or_within hemopoiesis  
    involved_in intracellular signal transduction PubMed 
    involved_in intracellular signal transduction  
    involved_in maintenance of protein location in mitochondrion  
    involved_in maintenance of protein location in mitochondrion  
    involved_in mitochondrion organization  
    involved_in mitochondrion organization  
    involved_in mitochondrion to lysosome vesicle-mediated transport  
    involved_in mitochondrion to lysosome vesicle-mediated transport  
    involved_in mitophagy  
    involved_in mitophagy  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of autophagosome assembly  
    involved_in negative regulation of autophagosome assembly  
    involved_in negative regulation of gene expression PubMed 
    involved_in negative regulation of gene expression  
    involved_in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway  
    involved_in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway  
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway  
    involved_in negative regulation of intrinsic apoptotic signaling pathway  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide  
    involved_in negative regulation of macroautophagy  
    involved_in negative regulation of mitochondrial fission  
    involved_in negative regulation of mitochondrial fission  
    involved_in negative regulation of mitophagy  
    involved_in negative regulation of mitophagy  
    involved_in negative regulation of neuron apoptotic process PubMed 
    involved_in negative regulation of neuron apoptotic process  
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  
    involved_in negative regulation of reactive oxygen species metabolic process  
    involved_in negative regulation of reactive oxygen species metabolic process  
    involved_in peptidyl-serine autophosphorylation  
    involved_in peptidyl-serine phosphorylation  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    acts_upstream_of_or_within positive regulation of catecholamine secretion PubMed 
    involved_in positive regulation of cristae formation  
    involved_in positive regulation of cristae formation  
    acts_upstream_of_or_within positive regulation of dopamine secretion PubMed 
    involved_in positive regulation of macroautophagy  
    acts_upstream_of_or_within positive regulation of mitochondrial electron transport, NADH to ubiquinone PubMed 
    involved_in positive regulation of mitochondrial fission  
    involved_in positive regulation of mitochondrial fission  
    involved_in positive regulation of mitochondrial fission  
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of release of cytochrome c from mitochondria  
    involved_in positive regulation of release of cytochrome c from mitochondria  
    acts_upstream_of_or_within positive regulation of synaptic transmission, dopaminergic PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of translation PubMed 
    involved_in positive regulation of type 2 mitophagy  
    involved_in positive regulation of type 2 mitophagy  
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    involved_in protein stabilization PubMed 
    involved_in protein stabilization  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in regulation of apoptotic process  
    involved_in regulation of cellular response to oxidative stress  
    involved_in regulation of cellular response to oxidative stress  
    involved_in regulation of hydrogen peroxide metabolic process PubMed 
    involved_in regulation of mitochondrial membrane potential  
    involved_in regulation of mitochondrial membrane potential  
    involved_in regulation of mitochondrion organization  
    involved_in regulation of neuron apoptotic process PubMed 
    involved_in regulation of oxidative phosphorylation  
    involved_in regulation of oxidative phosphorylation  
    involved_in regulation of protein targeting to mitochondrion  
    involved_in regulation of protein targeting to mitochondrion  
    involved_in regulation of protein ubiquitination  
    involved_in regulation of protein ubiquitination  
    involved_in regulation of protein-containing complex assembly  
    involved_in regulation of protein-containing complex assembly  
    involved_in regulation of reactive oxygen species metabolic process  
    involved_in respiratory electron transport chain PubMed 
    involved_in response to ischemia  
    involved_in response to oxidative stress  
    Items 1 - 25 of 97
    Items 1 - 20 of 33
    Component Evidence Code Pubs
    located_in astrocyte projection  
    located_in astrocyte projection  
    located_in axon  
    located_in cell body  
    located_in cell body  
    located_in chromatin  
    located_in chromatin  
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in cytoskeleton  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum  
    located_in growth cone  
    located_in growth cone  
    located_in membrane  
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrial inner membrane  
    located_in mitochondrial intermembrane space  
    located_in mitochondrial intermembrane space  
    located_in mitochondrial outer membrane  
    located_in mitochondrial outer membrane  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    Items 1 - 20 of 33

    General protein information

    Preferred Names
    serine/threonine-protein kinase PINK1, mitochondrial
    Names
    PTEN-induced putative kinase protein 1
    NP_081156.2
    XP_036020293.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026880.2NP_081156.2  serine/threonine-protein kinase PINK1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_081156.2

      Status: VALIDATED

      Source sequence(s)
      BC067066, CX238874
      Consensus CDS
      CCDS18825.1
      UniProtKB/Swiss-Prot
      A2AM77, Q7TMZ3, Q811I8, Q91XU5, Q99MQ3
      UniProtKB/TrEMBL
      Q3U258
      Related
      ENSMUSP00000030536.7, ENSMUST00000030536.13
      Conserved Domains (1) summary
      cd14018
      Location:162511
      STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      138040718..138053631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164400.1XP_036020293.1  serine/threonine-protein kinase PINK1, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q3U258
      Conserved Domains (1) summary
      cd14018
      Location:162523
      STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
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