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    Lncpint long non-protein coding RNA, Trp53 induced transcript [ Mus musculus (house mouse) ]

    Gene ID: 232685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lncpintprovided by MGI
    Official Full Name
    long non-protein coding RNA, Trp53 induced transcriptprovided by MGI
    Primary source
    MGI:MGI:2673128
    See related
    Ensembl:ENSMUSG00000044471 AllianceGenome:MGI:2673128
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pint; Lincpint; MNCb-1768; linc-Pint
    Summary
    Involved in several processes, including bone mineralization; hair follicle development; and skeletal muscle fiber development. Acts upstream of or within adult somatic muscle development and skin development. Orthologous to human LINC-PINT (long intergenic non-protein coding RNA, p53 induced transcript). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 1.5), adrenal adult (RPKM 1.4) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lncpint in Genome Data Viewer
    Location:
    6 A3.3; 6 12.56 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (31070498..31195409, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (31093563..31218474, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene microRNA 29b-1 Neighboring gene microRNA 29a Neighboring gene STARR-seq mESC enhancer starr_15479 Neighboring gene STARR-positive B cell enhancer ABC_E11314 Neighboring gene STARR-positive B cell enhancer ABC_E6423 Neighboring gene STARR-positive B cell enhancer mm9_chr6:31119400-31119700 Neighboring gene STARR-positive B cell enhancer ABC_E8097 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15481 Neighboring gene RIKEN cDNA 2210408F21 gene Neighboring gene STARR-seq mESC enhancer starr_15482 Neighboring gene STARR-seq mESC enhancer starr_15483 Neighboring gene STARR-positive B cell enhancer ABC_E4819 Neighboring gene predicted gene, 38782 Neighboring gene STARR-seq mESC enhancer starr_15487 Neighboring gene muskelin 1, intracellular mediator containing kelch motifs, opposite strand Neighboring gene muskelin 1, intracellular mediator containing kelch motifs

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A lncRNA survey finds increases in neuroprotective LINC-PINT in Parkinson's disease substantia nigra. Simchovitz A, et al. Aging Cell, 2020 Mar. PMID 32080970, Free PMC Article
    2. Inhibition of Lincpint expression affects insulin secretion and apoptosis in mouse pancreatic β cells. Zhu Y, et al. Int J Biochem Cell Biol, 2018 Nov. PMID 30201298
    3. Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2. Marín-Béjar O, et al. Genome Biol, 2013. PMID 24070194, Free PMC Article
    4. Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs. Lai KM, et al. PLoS One, 2015. PMID 25909911, Free PMC Article
    5. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Sauvageau M, et al. Elife, 2013 Dec 31. PMID 24381249, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A lncRNA survey finds increases in neuroprotective LINC-PINT in Parkinson's disease substantia nigra.
      Title: A lncRNA survey finds increases in neuroprotective LINC-PINT in Parkinson's disease substantia nigra.
    2. Inhibition of Lincpint expression affects insulin secretion and apoptosis in mouse pancreatic beta cells
      Title: Inhibition of Lincpint expression affects insulin secretion and apoptosis in mouse pancreatic β cells.
    3. Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2.
      Title: Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Other Names

    • long intergenic non-protein coding RNA, Trp53 induced transcript
    • long intergenic non-protein coding RNA, p53 induced transcript

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within adult somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skin development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_110469.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) represents the longest transcript.
      Source sequence(s)
      AC024913, AC153820
      Related
      ENSMUST00000185982.9

    2. NR_110470.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) lacks an alternate internal exon, resulting in a shorter transcript, compared to variant A.
      Source sequence(s)
      AC024913, AC153820
      Related
      ENSMUST00000346448.1

    3. NR_110471.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (C) lacks two alternate internal exons and differs in the 3' exon structure, resulting in a shorter transcript, compared to variant A.
      Source sequence(s)
      AC024913, AC153820
      Related
      ENSMUST00000187876.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      31070498..31195409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144555.1: Suppressed sequence

      Description
      NM_144555.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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