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    Insyn2a inhibitory synaptic factor 2A [ Mus musculus (house mouse) ]

    Gene ID: 627214, updated on 9-Dec-2024

    Summary

    Official Symbol
    Insyn2aprovided by MGI
    Official Full Name
    inhibitory synaptic factor 2Aprovided by MGI
    Primary source
    MGI:MGI:3605068
    See related
    Ensembl:ENSMUSG00000073805 AllianceGenome:MGI:3605068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    InSyn2; Fam196a; B830028B13Rik
    Summary
    Involved in inhibitory postsynaptic potential. Located in postsynaptic density. Is active in GABA-ergic synapse and postsynaptic specialization. Orthologous to human INSYN2A (inhibitory synaptic factor 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 1.9), CNS E18 (RPKM 1.8) and 12 other tissues See more
    Orthologs
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    Genomic context

    See Insyn2a in Genome Data Viewer
    Location:
    7 F3; 7 80.86 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (134483637..134540159, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (134881908..134938430, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 7, ERATO Doi 443, expressed Neighboring gene STARR-seq mESC enhancer starr_20343 Neighboring gene predicted gene, 35970 Neighboring gene STARR-seq mESC enhancer starr_20344 Neighboring gene STARR-seq mESC enhancer starr_20345 Neighboring gene STARR-seq mESC enhancer starr_20346 Neighboring gene methionine aminopeptidase 2 pseudogene Neighboring gene dedicator of cytokinesis 1 Neighboring gene STARR-seq mESC enhancer starr_20355 Neighboring gene STARR-seq mESC enhancer starr_20356 Neighboring gene VISTA enhancer mm1401 Neighboring gene RIKEN cDNA 1700120G07 gene Neighboring gene STARR-seq mESC enhancer starr_20359 Neighboring gene predicted gene, 24581

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General protein information

    Preferred Names
    inhibitory synaptic factor 2A
    Names
    family with sequence similarity 196, member A
    protein FAM196A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143802.1NP_001137274.1  inhibitory synaptic factor 2A

      Status: VALIDATED

      Source sequence(s)
      AC100208, AC127574
      Consensus CDS
      CCDS52419.1
      UniProtKB/Swiss-Prot
      B2RY32, Q3USH1
      UniProtKB/TrEMBL
      E9PZW7
      Related
      ENSMUSP00000129222.2, ENSMUST00000171394.3
      Conserved Domains (1) summary
      pfam15265
      Location:1470
      FAM196; FAM196 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      134483637..134540159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508103.5XP_006508166.1  inhibitory synaptic factor 2A isoform X2

      UniProtKB/Swiss-Prot
      B2RY32, Q3USH1
      Conserved Domains (1) summary
      pfam15265
      Location:19464
      FAM196; FAM196 family
    2. XM_017322443.3XP_017177932.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RY32, Q3USH1
      Conserved Domains (1) summary
      pfam15265
      Location:19488
      FAM196; FAM196 family