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    Mrgprb1 MAS-related GPR, member B1 [ Mus musculus (house mouse) ]

    Gene ID: 233231, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mrgprb1provided by MGI
    Official Full Name
    MAS-related GPR, member B1provided by MGI
    Primary source
    MGI:MGI:3033115
    See related
    Ensembl:ENSMUSG00000070547 AllianceGenome:MGI:3033115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MrgB1
    Summary
    Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; mast cell degranulation; and positive regulation of cytokinesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human MRGPRX2 (MAS related GPR family member X2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Mrgprb1 in Genome Data Viewer
    Location:
    7 B4; 7 31.11 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (48093861..48106090, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (48444113..48456342, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene MAS-related GPR, member B8 Neighboring gene DNA-directed RNA polymerases I, II, and III subunit RPABC4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18883 Neighboring gene STARR-seq mESC enhancer starr_18884 Neighboring gene MAS-related GPR, member X2 Neighboring gene STARR-seq mESC enhancer starr_18885 Neighboring gene MAS-related GPR, member B2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity  
    enables G protein-coupled receptor activity  
    enables G protein-coupled receptor activity  
    enables neuropeptide binding  
    Component Evidence Code Pubs
    located_in membrane  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    mas-related G-protein coupled receptor member B1
    Names
    MrgB1 G protein-coupled receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205810.4 → NP_991379.3  mas-related G-protein coupled receptor member B1

      See identical proteins and their annotated locations for NP_991379.3

      Status: VALIDATED

      Source sequence(s)
      AK148114, AK148279
      Consensus CDS
      CCDS52257.1
      UniProtKB/Swiss-Prot
      A4FUT5, A4QMY7, Q3UFN5, Q3UFT1, Q3UFW7, Q3UFX0, Q3UFX7, Q3UFY5, Q3UG23, Q3UG61, Q3UG95, Q91ZC3
      UniProtKB/TrEMBL
      W8W3M3
      Related
      ENSMUSP00000091946.4, ENSMUST00000094384.4
      Conserved Domains (1) summary
      cd15107
      Location:43 → 318
      7tmA_MrgprB; mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      48093861..48106090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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