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    Gmps guanine monophosphate synthetase [ Mus musculus (house mouse) ]

    Gene ID: 229363, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gmpsprovided by MGI
    Official Full Name
    guanine monophosphate synthetaseprovided by MGI
    Primary source
    MGI:MGI:2448526
    See related
    Ensembl:ENSMUSG00000027823 AllianceGenome:MGI:2448526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    670032; Gm9479
    Summary
    Enables GMP synthase (glutamine-hydrolyzing) activity. Involved in GMP biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human GMPS (guanine monophosphate synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.1), testis adult (RPKM 10.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gmps in Genome Data Viewer
    Location:
    3 E1; 3 30.08 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (63871054..63928975)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (63963633..64021554)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130311K13 gene Neighboring gene predicted gene, 34379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:63768480-63768744 Neighboring gene solute carrier family 33 (acetyl-CoA transporter), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E2666 Neighboring gene STARR-seq mESC enhancer starr_07841 Neighboring gene vomeronasal 2, receptor, pseudogene 3 Neighboring gene vomeronasal 2, receptor 1 Neighboring gene predicted gene, 22165

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Studies with GMP synthetase from Ehrlich ascites cells. Purification, properties, and interactions with nucleotide analogs. Spector T. J Biol Chem, 1975 Sep 25. PMID 240826
    2. Characterization of purine nucleotide metabolism in primary rat muscle cultures. Zoref-Shani E, et al. Biochim Biophys Acta, 1982 Jun 16. PMID 6180773
    3. Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer. Holzer K, et al. Am J Pathol, 2017 Feb. PMID 27939741
    4. Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway. Mechoud MA, et al. Appl Environ Microbiol, 2020 Jul 2. PMID 32414791, Free PMC Article
    5. ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. Cozzolino F, et al. Hum Mol Genet, 2021 Jun 17. PMID 33601422

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GMP synthase (glutamine-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GMP synthase (glutamine-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GMP synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GMP synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within GMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GMP salvage ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in response to L-cysteine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    GMP synthase [glutamine-hydrolyzing]
    Names
    GMP synthase
    GMP synthetase
    glutamine amidotransferase
    NP_001028472.2
    XP_011238380.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033300.2 → NP_001028472.2  GMP synthase [glutamine-hydrolyzing]

      See identical proteins and their annotated locations for NP_001028472.2

      Status: VALIDATED

      Source sequence(s)
      AK049755, AK136966, AK143197, CN528611
      Consensus CDS
      CCDS17383.1
      UniProtKB/Swiss-Prot
      Q3TFR6, Q3THK7, Q3TIH1, Q3UJ21, Q3V343, Q66JZ6
      UniProtKB/TrEMBL
      B2RRH9
      Related
      ENSMUSP00000029405.8, ENSMUST00000029405.8
      Conserved Domains (3) summary
      cd01742
      Location:28 → 207
      GATase1_GMP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase
      PRK00074
      Location:28 → 693
      guaA; GMP synthase; Reviewed
      cd01997
      Location:238 → 692
      GMP_synthase_C; The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      63871054..63928975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240078.3 → XP_011238380.1  GMP synthase [glutamine-hydrolyzing] isoform X1

      Conserved Domains (1) summary
      PRK00074
      Location:80 → 745
      guaA; GMP synthase; Reviewed
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3THK7.2 GenPept UniProtKB/Swiss-Prot:Q3THK7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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