Fam83g family with sequence similarity 83, member G [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fam83gprovided by MGI
Official Full Name: family with sequence similarity 83, member Gprovided by MGI
Primary source: MGI:MGI:1916890
See related: Ensembl:ENSMUSG00000042377 AllianceGenome:MGI:1916890
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: wly; 2310040C09Rik
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in BMP signaling pathway. Predicted to be active in cytosol and nucleus. Orthologous to human FAM83G (family with sequence similarity 83 member G). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 24.2), duodenum adult (RPKM 11.9) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.96 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (61574908..61600776)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (61684058..61709950)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FAM83G promotes proliferation, invasion, and metastasis by regulating PI3K/AKT signaling in hepatocellular carcinoma cells.
Title: FAM83G promotes proliferation, invasion, and metastasis by regulating PI3K/AKT signaling in hepatocellular carcinoma cells.
In this study, we demonstrate that FAM83G/Fam83g is associated with hair morphogenesis, differentiation and cycling and provide first insights into functional consequences of FAM83G/Fam83g variants.
Title: FAM83G/Fam83g genetic variants affect canine and murine hair formation.
suggest that this mutation in Fam83g is the likely basis of the mouse wooly phenotype
Title: The wooly mutation (wly) on mouse chromosome 11 is associated with a genetic defect in Fam83g.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236602

AI506990 (e-PCR)
- UniSTS:180223

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein FAM83G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178618.3 → NP_848733.2 protein FAM83G

See identical proteins and their annotated locations for NP_848733.2

Status: VALIDATED

Source sequence(s)

AK009716, BC085279, BX631674, BY062936

Consensus CDS

CCDS36175.1

UniProtKB/Swiss-Prot

Q5SWY7, Q5U437, Q8C1B0

Related

ENSMUSP00000090697.6, ENSMUST00000093019.6

Conserved Domains (1) summary

cl15239
Location:20 → 307

PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

61574908..61600776

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534119.5 → XP_006534182.1 protein FAM83G isoform X1

See identical proteins and their annotated locations for XP_006534182.1

UniProtKB/Swiss-Prot

Q5SWY7, Q5U437, Q8C1B0

Conserved Domains (1) summary

cl15239
Location:20 → 307

PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
XM_006534120.5 → XP_006534183.1 protein FAM83G isoform X2

Conserved Domains (1) summary

cl15239
Location:20 → 307

PLDc_SF; Catalytic domain of phospholipase D superfamily proteins