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    Bag3 BCL2-associated athanogene 3 [ Mus musculus (house mouse) ]

    Gene ID: 29810, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bag3provided by MGI
    Official Full Name
    BCL2-associated athanogene 3provided by MGI
    Primary source
    MGI:MGI:1352493
    See related
    Ensembl:ENSMUSG00000030847 AllianceGenome:MGI:1352493
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bis; mg638
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity and protein-folding chaperone binding activity. Involved in muscle cell cellular homeostasis. Acts upstream of or within several processes, including cellular response to mechanical stimulus; extrinsic apoptotic signaling pathway in absence of ligand; and protein stabilization. Located in Z disc. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Used to study dilated cardiomyopathy 1HH. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1HH and myofibrillar myopathy 6. Orthologous to human BAG3 (BAG cochaperone 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 127.9), heart adult (RPKM 49.8) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Bag3 in Genome Data Viewer
    Location:
    7 F3; 7 70.26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (128125307..128148705)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (128523583..128546981)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20203 Neighboring gene predicted gene, 57509 Neighboring gene predicted gene, 40457 Neighboring gene STARR-seq mESC enhancer starr_20208 Neighboring gene STARR-positive B cell enhancer ABC_E1743 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3756 Neighboring gene inositol polyphosphate-5-phosphatase F Neighboring gene pentatricopeptide repeat domain 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables adenyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cellular response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in muscle cell cellular homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in muscle cell cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein targeting to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of striated muscle cell apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of striated muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of striated muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of aggrephagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of aggrephagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein import into nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spinal cord development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of striated muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein folding chaperone complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein folding chaperone complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    BAG family molecular chaperone regulator 3
    Names
    BAG-3
    Bcl-2-binding protein Bis
    Bcl-2-interacting death suppressor
    bcl-2-associated athanogene 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013863.5NP_038891.4  BAG family molecular chaperone regulator 3

      See identical proteins and their annotated locations for NP_038891.4

      Status: VALIDATED

      Source sequence(s)
      AC130474, AK007414, BY685079
      Consensus CDS
      CCDS21898.1
      UniProtKB/Swiss-Prot
      Q9CQL3, Q9JJC7, Q9JLV1
      UniProtKB/TrEMBL
      A6H663
      Related
      ENSMUSP00000033136.8, ENSMUST00000033136.9
      Conserved Domains (2) summary
      smart00456
      Location:2355
      WW; Domain with 2 conserved Trp (W) residues
      smart00264
      Location:426503
      BAG; BAG domains, present in regulator of Hsp70 proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      128125307..128148705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)