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    Trim61 tripartite motif-containing 61 [ Mus musculus (house mouse) ]

    Gene ID: 260296, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Trim61provided by MGI
    Official Full Name
    tripartite motif-containing 61provided by MGI
    Primary source
    MGI:MGI:2387432
    See related
    Ensembl:ENSMUSG00000109718 AllianceGenome:MGI:2387432
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnf35; 2czf61; E330039K03Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. Is expressed in central nervous system; early conceptus; secondary oocyte; and testis. Orthologous to human TRIM61 (tripartite motif containing 61). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 1.5) and kidney adult (RPKM 0.2) See more
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    Genomic context

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    See Trim61 in Genome Data Viewer
    Location:
    8 B3.1; 8 32.52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (65465628..65471340, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (65012976..65018688, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 192 Neighboring gene tripartite motif-containing 75 Neighboring gene tripartite motif-containing 60 Neighboring gene STARR-seq mESC enhancer starr_21646 Neighboring gene apelin receptor early endogenous ligand Neighboring gene STARR-seq mESC enhancer starr_21647 Neighboring gene predicted gene, 39183 Neighboring gene STARR-seq mESC enhancer starr_21648 Neighboring gene STARR-seq mESC enhancer starr_21650 Neighboring gene STARR-seq mESC enhancer starr_21651

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Different modes of regulation of transcription and pre-mRNA processing of the structurally juxtaposed homologs, Rnf33 and Rnf35, in eggs and in pre-implantation embryos. Choo KB, et al. Nucleic Acids Res, 2002 Nov 15. PMID 12433986, Free PMC Article
    2. Use of a common promoter by two juxtaposed and intronless mouse early embryonic genes, Rnf33 and Rnf35: implications in zygotic gene expression. Chen HH, et al. Genomics, 2002 Aug. PMID 12160726
    3. Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence. Huang CJ, et al. J Biol Chem, 2005 Sep 2. PMID 15994318
    4. Transcriptional modulation of the pre-implantation embryo-specific Rnf35 gene by the Y-box protein NF-Y/CBF. Huang CJ, et al. Biochem J, 2005 Apr 15. PMID 15516209, Free PMC Article
    5. Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse. Yu C, et al. Cell Res, 2016 Mar. PMID 26902285, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the Rnf35 promoter is negatively modulated by the repressor element, DER, and that the 3'-half of DER (DER2) was targeted by the repressor CCAAT-displacement protein (CDP)/Cux.
      Title: Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence.
    2. Regulation of transcription and pre-mRNA processing of Rnf35 in eggs and in pre-implantation embryos.
      Title: Different modes of regulation of transcription and pre-mRNA processing of the structurally juxtaposed homologs, Rnf33 and Rnf35, in eggs and in pre-implantation embryos.
    3. Rnf33 and Rnf35 mRNAs are apparently transcribed from the same putative promoter and may be products of alternative splicing.
      Title: Use of a common promoter by two juxtaposed and intronless mouse early embryonic genes, Rnf33 and Rnf35: implications in zygotic gene expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative tripartite motif-containing protein 61
    Names
    ring finger protein 35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177551.1 → NP_001171022.1  putative tripartite motif-containing protein 61

      See identical proteins and their annotated locations for NP_001171022.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK054544, BB709545, CF175045
      Consensus CDS
      CCDS22332.1
      UniProtKB/TrEMBL
      Q6P242, Q8JZK6
      Related
      ENSMUSP00000077513.4, ENSMUST00000078409.5
      Conserved Domains (2) summary
      cd15828
      Location:272 → 456
      SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)
      cl17238
      Location:16 → 56
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_153110.4 → NP_694750.3  putative tripartite motif-containing protein 61

      See identical proteins and their annotated locations for NP_694750.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK054544, BB709545, BC064738, CF175045
      Consensus CDS
      CCDS22332.1
      UniProtKB/TrEMBL
      Q6P242, Q8JZK6
      Conserved Domains (2) summary
      cd15828
      Location:272 → 456
      SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)
      cl17238
      Location:16 → 56
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      65465628..65471340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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