Mtmr11 myotubularin related protein 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtmr11provided by MGI
Official Full Name: myotubularin related protein 11provided by MGI
Primary source: MGI:MGI:2652817
See related: Ensembl:ENSMUSG00000045934 AllianceGenome:MGI:2652817
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cra
Summary: Predicted to enable phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in cytoplasm and membrane. Orthologous to human MTMR11 (myotubularin related protein 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 16.1), kidney adult (RPKM 14.9) and 25 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3 F2.1; 3 41.65 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (96069287..96079034)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (96161949..96171718)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

Go to the top of the page Help

Markers

MARC_10655-10656:1000474755:1 (e-PCR)
- UniSTS:267185

AI035306 (e-PCR)
- UniSTS:163315

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol-3-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: myotubularin-related protein 11

Names: cisplatin resistance associated; inactive phosphatidylinositol 3-phosphatase 11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181409.3 → NP_852074.2 myotubularin-related protein 11

See identical proteins and their annotated locations for NP_852074.2

Status: VALIDATED

Source sequence(s)

AK132375, BB203609, BY209090

Consensus CDS

CCDS51000.1

UniProtKB/Swiss-Prot

Q3V1L6, Q80UV0, Q8CG88

Related

ENSMUSP00000062341.10, ENSMUST00000054356.16

Conserved Domains (3) summary

pfam12578
Location:553 → 683

3-PAP; Myotubularin-associated protein

cl17171
Location:51 → 165

PH-like; Pleckstrin homology-like domain

cl21483
Location:195 → 469

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...