Krt36 keratin 36 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt36provided by MGI
Official Full Name: keratin 36provided by MGI
Primary source: MGI:MGI:109364
See related: Ensembl:ENSMUSG00000020916 AllianceGenome:MGI:109364
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K36; HRa-1; Krt1-5; MHRa-1; Krt1-22
Summary: A structural constituent of skin epidermis. Involved in regulation of keratinocyte differentiation. Located in intermediate filament cytoskeleton. Is expressed in several structures, including cranium; fronto-nasal process; skin; surface ectoderm; and tongue. Orthologous to human KRT36 (keratin 36). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in mammary gland adult (RPKM 2.2), subcutaneous fat pad adult (RPKM 0.7) and 7 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11 D; 11 63.41 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (99992838..100000301, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100102012..100109487, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84.
Title: E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of skin epidermis	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of keratinocyte differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in intermediate filament cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in keratin filament	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: keratin, type I cuticular Ha6

Names: keratin complex 1, acidic, gene 5; keratin-5; type I keratin 48 kDa (MHRa-1)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001174099.1 → NP_001167570.1 keratin, type I cuticular Ha6

See identical proteins and their annotated locations for NP_001167570.1

Status: VALIDATED

Source sequence(s)

AL590873, AL662808

Consensus CDS

CCDS48929.1

UniProtKB/Swiss-Prot

B1AQ75, Q61861

Related

ENSMUSP00000103039.3, ENSMUST00000107416.3

Conserved Domains (1) summary

pfam00038
Location:92 → 403

Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

99992838..100000301 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314302.2 → XP_017169791.1 keratin, type I cuticular Ha6 isoform X1

UniProtKB/Swiss-Prot

B1AQ75, Q61861

Conserved Domains (1) summary

pfam00038
Location:92 → 403

Filament; Intermediate filament protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_008472.2: Suppressed sequence

Description

NM_008472.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
NR_003957.1: Suppressed sequence

Description

NR_003957.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.