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    Ctps CTP synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39645, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ctpsprovided by FlyBase
    Official Full Name
    CTP synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266452
    Locus tag
    Dmel_CG45070
    See related
    AllianceGenome:FB:FBgn0266452
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG45070; CG6854; CTP syn; ctps; CTPS; CTPsyn; CTPSyn; dCTPS; Dmel\CG45070
    Old locus tag
    Dmel_CG6854
    Summary
    Enables CTP synthase activity. Involved in CTP biosynthetic process and larval lymph gland hemopoiesis. Acts upstream of with a positive effect on phospholipid metabolic process. Located in cytoophidium and cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; adult brain cell body rind; brain; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in immunodeficiency 24. Orthologous to human CTPS1 (CTP synthase 1) and CTPS2 (CTP synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ctps in Genome Data Viewer
    Location:
    71B4-71B5; 3-42 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15097914..15113003)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15091014..15106103)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Pericentrin-like protein Neighboring gene long non-coding RNA:CR43973 Neighboring gene stepping stone Neighboring gene Glycyl-tRNA synthetase Neighboring gene pseudo Neighboring gene antisense RNA:CR43971 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Centrosomal protein 135kDa Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CTP synthase polymerization in germline cells of the developing Drosophila egg supports egg production. Simonet JC, et al. Biol Open, 2020 Jul 21. PMID 32580972, Free PMC Article
    2. Cytoophidia: a conserved yet promising mode of enzyme regulation in nucleotide metabolism. Yin Y, et al. Mol Biol Rep, 2024 Feb 1. PMID 38300325
    3. Drosophila CTP synthase can form distinct substrate- and product-bound filaments. Zhou X, et al. J Genet Genomics, 2019 Nov 20. PMID 31902586
    4. MicroRNA regulation of CTP synthase and cytoophidium in Drosophila melanogaster. Dzaki N, et al. Exp Cell Res, 2019 Dec 15. PMID 31678212
    5. Cytoophidia and filaments: you must unlearn what you have learned. Guo CJ, et al. Biochem Soc Trans, 2023 Jun 28. PMID 37248970

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural Basis of Bifunctional CTP/dCTP Synthase.
      Title: Structural Basis of Bifunctional CTP/dCTP Synthase.
    2. Polarised maintenance of cytoophidia in Drosophila follicle epithelia.
      Title: Polarised maintenance of cytoophidia in Drosophila follicle epithelia.
    3. The atlas of cytoophidia in Drosophila larvae.
      Title: The atlas of cytoophidia in Drosophila larvae.
    4. The proline synthesis enzyme P5CS forms cytoophidia in Drosophila.
      Title: The proline synthesis enzyme P5CS forms cytoophidia in Drosophila.
    5. the role of the conserved N-terminal of Drosophila CTP synthase in cytoophidium assembly, is reported.
      Title: Critical roles of CTP synthase N-terminal in cytoophidium assembly.
    6. a functional link between Myc, a renowned oncogene, and the essential nucleotide biosynthetic enzyme CTPsyn.
      Title: The Interplay between Myc and CTP Synthase in Drosophila.
    7. CTPsyn is critical for optic lobe homeostasis in Drosophila
      Title: CTP Synthase Is Required for Optic Lobe Homeostasis in Drosophila.
    8. the study of multiple isoforms of CTP synthase in Drosophila provides a good opportunity to dissect the biogenesis and function of the cytoophidum in a genetically tractable organism.
      Title: Only one isoform of Drosophila melanogaster CTP synthase forms the cytoophidium.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables CTP synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CTP synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CTP synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CTP synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in CTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CTP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CTP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in CTP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in larval lymph gland hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect phospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyrimidine nucleobase biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoophidium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoophidium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    CTP synthase
    Names
    CG45070-PA
    CG45070-PB
    CG45070-PC
    CTP synthetase
    CTP-synthase
    Ctps-PA
    Ctps-PB
    Ctps-PC
    ctp synthase
    cytidine synthase
    NP_001287067.1
    NP_648747.1
    NP_730023.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15097914..15113003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300138.1 → NP_001287067.1  CTP synthase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287067.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VUL0, Q9VUL1
      UniProtKB/TrEMBL
      X2JCY2
      Conserved Domains (1) summary
      PLN02327
      Location:1 → 556
      PLN02327; CTP synthase

    2. NM_168606.2 → NP_730023.1  CTP synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730023.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VUL0, Q9VUL1
      UniProtKB/TrEMBL
      X2JCY2
      Related
      FBpp0310803
      Conserved Domains (1) summary
      PLN02327
      Location:1 → 556
      PLN02327; CTP synthase

    3. NM_140490.4 → NP_648747.1  CTP synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648747.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VUL1
      Related
      FBpp0310804
      Conserved Domains (4) summary
      cd01746
      Location:295 → 540
      GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
      pfam00117
      Location:308 → 542
      GATase; Glutamine amidotransferase class-I
      pfam06418
      Location:53 → 267
      CTP_synth_N; CTP synthase N-terminus
      cl23759
      Location:14 → 53
      GT1; GT1, myb-like, SANT family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUL1.2 Q9VUL1
    X2JCY2 X2JCY2

    Gene LinkOut

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