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    PNPase Polynucleotide phosphorylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43710, updated on 27-Dec-2024

    Summary

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    Official Symbol
    PNPaseprovided by FlyBase
    Official Full Name
    Polynucleotide phosphorylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039846
    Locus tag
    Dmel_CG11337
    See related
    AllianceGenome:FB:FBgn0039846
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11337; Dmel\CG11337; dmpnpase
    Summary
    Predicted to enable 3'-5'-RNA exonuclease activity and polyribonucleotide nucleotidyltransferase activity. Involved in mitochondrial mRNA catabolic process; mitochondrial mRNA polyadenylation; and regulation of mitochondrial mRNA stability. Located in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval central nervous system; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 70; combined oxidative phosphorylation deficiency 13; and spinocerebellar ataxia type 25. Orthologous to human PNPT1 (polyribonucleotide nucleotidyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PNPase in Genome Data Viewer
    Location:
    100C3-100C3; 3-102 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31401560..31405452, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27227282..27231174, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 35 member D1 Neighboring gene Gcn2 Neighboring gene G protein-coupled receptor kinase 2 Neighboring gene uncharacterized protein Neighboring gene Lysyl oxidase-like 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUV3 helicase is required for correct processing of mitochondrial transcripts. Clemente P, et al. Nucleic Acids Res, 2015 Sep 3. PMID 26152302, Free PMC Article
    2. Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo. Pajak A, et al. PLoS Genet, 2019 Jul. PMID 31365523, Free PMC Article
    3. G protein-coupled receptor kinase 2 is required for rhythmic olfactory responses in Drosophila. Tanoue S, et al. Curr Biol, 2008 Jun 3. PMID 18499458, Free PMC Article
    4. The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Molnar C, et al. Proc Natl Acad Sci U S A, 2007 May 8. PMID 17483466, Free PMC Article
    5. Regulation of smoothened by Drosophila G-protein-coupled receptor kinases. Cheng S, et al. Dev Biol, 2010 Jan 1. PMID 19850026, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyribonucleotide nucleotidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyribonucleotide nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial RNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial mRNA polyadenylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polynucleotide phosphorylase
    Names
    CG11337-PA
    CG11337-PB
    CG11337-PD
    CG11337-PE
    PNPase-PA
    PNPase-PB
    PNPase-PD
    PNPase-PE
    NP_001097990.2
    NP_001163783.1
    NP_651867.2
    NP_733429.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31401560..31405452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170312.1 → NP_001163783.1  polynucleotide phosphorylase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRH9, Q5U1D1, Q9V9X7
      Conserved Domains (1) summary
      PRK11824
      Location:42 → 751
      PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional

    2. NM_170550.2 → NP_733429.1  polynucleotide phosphorylase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733429.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRH9, Q5U1D1, Q9V9X7
      Related
      FBpp0085172
      Conserved Domains (1) summary
      PRK11824
      Location:42 → 751
      PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional

    3. NM_001104520.3 → NP_001097990.2  polynucleotide phosphorylase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097990.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRH9, Q5U1D1, Q9V9X7
      Conserved Domains (1) summary
      PRK11824
      Location:42 → 751
      PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional

    4. NM_143610.3 → NP_651867.2  polynucleotide phosphorylase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651867.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRH9, Q5U1D1, Q9V9X7
      Related
      FBpp0085173
      Conserved Domains (1) summary
      PRK11824
      Location:42 → 751
      PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U1D1 Q5U1D1
    Q8IH29 Q8IH29
    Q95RX7 Q95RX7
    Q9V9X7 Q9V9X7

    Gene LinkOut

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