Dgat2 Diacylglycerol O-acyltransferase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dgat2provided by FlyBase
Official Full Name: Diacylglycerol O-acyltransferase 2provided by FlyBase
Primary source: FLYBASE:FBgn0033215
Locus tag: Dmel_CG1942
See related: AllianceGenome:FB:FBgn0033215
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1942; DGAT; DGAT2; Dmel\CG1942
Summary: Predicted to enable diacylglycerol O-acyltransferase activity. Involved in lipid droplet organization. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; amnioserosa; head mesoderm; plasmatocyte primordium; and procrystal cell. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to several human genes including MOGAT1 (monoacylglycerol O-acyltransferase 1); MOGAT2 (monoacylglycerol O-acyltransferase 2); and MOGAT3 (monoacylglycerol O-acyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7712578..7714182)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3600083..3601687)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diacylglycerol O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lipid droplet organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	NAS Non-traceable Author Statement more info	PubMed
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_610318.1

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The following sections contain reference sequences that belong to a specific genome build. Explain