Pldn Pallidin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pldnprovided by FlyBase
Official Full Name: Pallidinprovided by FlyBase
Primary source: FLYBASE:FBgn0036192
Locus tag: Dmel_CG14133
See related: AllianceGenome:FB:FBgn0036192
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14133; Dmel\CG14133; NP_648494; pallidin; pldn
Summary: Involved in eye pigment granule organization; regulation of synaptic vesicle cycle; and synaptic vesicle recycling via endosome. Located in postsynapse of neuromuscular junction and type I terminal bouton. Part of BLOC-1 complex. Is active in neuromuscular junction. Used to study Hermansky-Pudlak syndrome 9. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 9. Orthologous to human BLOC1S6 (biogenesis of lysosomal organelles complex 1 subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11689631..11691399, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11682731..11684499, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in eye pigment granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic vesicle cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle recycling via endosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of BLOC-1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BLOC-1 complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of BLOC-1 complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynapse of neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in type I terminal bouton	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain