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    Had1 beta Hydroxy acid dehydrogenase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32592, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Had1provided by FlyBase
    Official Full Name
    beta Hydroxy acid dehydrogenase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0286508
    Locus tag
    Dmel_CG9914
    See related
    AllianceGenome:FB:FBgn0286508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9914; CRYL1; Dmel\CG9914; Had; HAD
    Summary
    Enables L-gulonate 3-dehydrogenase activity. Predicted to be involved in D-glucuronate catabolic process to D-xylulose 5-phosphate. Predicted to be active in cytosol. Is expressed in adult head and adult heart. Orthologous to human CRYL1 (crystallin lambda 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Had1 in Genome Data Viewer
    Location:
    14B9-14B9; 1-53 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16306912..16308667, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16200945..16202700, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene cabeza Neighboring gene Endoplasmic reticulum protein 44 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45485 Neighboring gene uncharacterized protein Neighboring gene Strumpellin and WASH-interacting protein Neighboring gene Cyclophilin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetics and physiological expression of beta-hydroxy acid dehydrogenase in Drosophila. Tobler JE, et al. Biochem Genet, 1978 Apr. PMID 28119
    2. Drosophila beta-L-hydroxy acid dehydrogenase. Purification and properties. Borack LI, et al. J Biol Chem, 1971 Sep 10. PMID 4328697
    3. Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. Silva B, et al. Nat Metab, 2022 Feb. PMID 35177854, Free PMC Article
    4. Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. Terhzaz S, et al. J Biol Chem, 2006 Jul 7. PMID 16670086
    5. Cis-regulatory variation is typically polyallelic in Drosophila. Gruber JD, et al. Genetics, 2009 Feb. PMID 19064705, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-gulonate 3-dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-gulonate 3-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-gulonate 3-dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    beta hydroxy acid dehydrogenase 1
    Names
    3-hydroxyacyl-CoA dehydrogenase
    B-L-hydroxy acid dehydrogenase
    CG9914-PA
    CG9914-PB
    Enoyl-CoA hydratase mitochondrial
    Had1-PA
    Had1-PB
    beta hydroxy acid dehydrogenase
    beta-L-hydroxy acid dehydrogenase
    beta-hydroxy acid dehydrogenase
    NP_001285320.1
    NP_573114.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16306912..16308667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298391.1 → NP_001285320.1  beta hydroxy acid dehydrogenase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU75, Q9VXI1
      Conserved Domains (3) summary
      PRK06129
      Location:7 → 310
      PRK06129; 3-hydroxyacyl-CoA dehydrogenase; Validated
      pfam00725
      Location:191 → 265
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:7 → 183
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

    2. NM_132886.3 → NP_573114.2  beta hydroxy acid dehydrogenase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573114.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU75, Q9VXI1
      Related
      FBpp0074019
      Conserved Domains (3) summary
      PRK06129
      Location:7 → 310
      PRK06129; 3-hydroxyacyl-CoA dehydrogenase; Validated
      pfam00725
      Location:191 → 265
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:7 → 183
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXI1 Q9VXI1

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