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    btn buttonless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42664, updated on 17-Dec-2024

    Summary

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    Official Symbol
    btnprovided by FlyBase
    Official Full Name
    buttonlessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014949
    Locus tag
    Dmel_CG5264
    See related
    AllianceGenome:FB:FBgn0014949
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1261/13; BTN; btn/MEOX; CG5264; Dmel\CG5264
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Is expressed in several structures, including anlage in statu nascendi; central brain anlage in statu nascendi; embryonic ventral epidermis; larval foregut atrium; and larval thoracic perisympathetic organ. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 2. Orthologous to several human genes including MEOX2 (mesenchyme homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See btn in Genome Data Viewer
    Location:
    94B5-94B5; 3-75 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22586149..22586625, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18411871..18412347, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 6 Neighboring gene uncharacterized protein Neighboring gene Diphthamide methyltransferase Neighboring gene uncharacterized protein Neighboring gene Exchange factor for Arf 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The novel homeodomain gene buttonless specifies differentiation and axonal guidance functions of Drosophila dorsal median cells. Chiang C, et al. Development, 1994 Dec. PMID 7821224
    2. CNS midline to mesoderm signaling in Drosophila. Zhou L, et al. Mech Dev, 1997 Sep. PMID 9347915
    3. Induction of identified mesodermal cells by CNS midline progenitors in Drosophila. Lüer K, et al. Development, 1997 Jul. PMID 9226439
    4. Cloning, mapping and tissue-specific expression of Drosophila clathrin-associated protein AP50 gene. Zhang YQ, et al. Gene, 1999 Jun 11. PMID 10375633
    5. Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Proc Natl Acad Sci U S A, 2022 May 31. PMID 35617426, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    buttonless
    Names
    CG5264-PA
    btn-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22586149..22586625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170026.2 → NP_732768.1  buttonless [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732768.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0IGT7, Q9VCY0
      Related
      FBpp0083671
      Conserved Domains (1) summary
      pfam00046
      Location:90 → 142
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U984 Q9U984
    Q9VCY0 Q9VCY0

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