Wars1 tryptophanyl-tRNA synthetase1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wars1provided by MGI
Official Full Name: tryptophanyl-tRNA synthetase1provided by MGI
Primary source: MGI:MGI:104630
See related: Ensembl:ENSMUSG00000021266 AllianceGenome:MGI:104630
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: WRS; Wars; TrpRS
Summary: Enables tryptophan-tRNA ligase activity. Involved in tryptophanyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 173.4), colon adult (RPKM 54.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 59.66 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (108825956..108860095, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (108860030..108894175, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-Cell RNA Sequencing Identifies WARS1+ Mesenchymal Stem Cells with Enhanced Immunomodulatory Capacity and Improved Therapeutic Efficacy.
Title: Single-Cell RNA Sequencing Identifies WARS1+ Mesenchymal Stem Cells with Enhanced Immunomodulatory Capacity and Improved Therapeutic Efficacy.
Highly secreted tryptophanyl tRNA synthetase 1 as a potential theranostic target for hypercytokinemic severe sepsis.
Title: Highly secreted tryptophanyl tRNA synthetase 1 as a potential theranostic target for hypercytokinemic severe sepsis.
TrpRS plays a role in protecting against neurodegeneration is suggested, providing an insight into the pathogenesis and a possible treatment of neurodegenerative diseases.
Title: Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wars (e-PCR), detects polymorphism
- UniSTS:534559

Wars (e-PCR), detects polymorphism
- UniSTS:547174

40.MMHAP79FLF4.seq (e-PCR)
- UniSTS:124381

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables tryptophan-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tryptophan-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables tryptophan-tRNA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tryptophan-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables tryptophan-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in tryptophanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tryptophanyl-tRNA aminoacylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tryptophan--tRNA ligase, cytoplasmic

Names: tryptophanyl-tRNA synthetase, cytoplasmic

NP_001157786.1

EC 6.1.1.2

NP_001157960.1

EC 6.1.1.2

NP_001398836.1

EC 6.1.1.2

NP_001398837.1

EC 6.1.1.2

NP_001398838.1

EC 6.1.1.2

NP_001398839.1

EC 6.1.1.2

NP_035840.3

EC 6.1.1.2

XP_006515882.1

EC 6.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164314.2 → NP_001157786.1 tryptophan--tRNA ligase, cytoplasmic isoform 2

See identical proteins and their annotated locations for NP_001157786.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AC122811, AC152061

Consensus CDS

CCDS49171.1

UniProtKB/TrEMBL

Q3U6U7, Q3UDG2

Related

ENSMUSP00000105474.4, ENSMUST00000109848.10

Conserved Domains (3) summary

PLN02486
Location:89 → 470

PLN02486; aminoacyl-tRNA ligase

TIGR00233
Location:158 → 467

trpS; tryptophanyl-tRNA synthetase

pfam00458
Location:16 → 68

WHEP-TRS; WHEP-TRS domain
NM_001164488.2 → NP_001157960.1 tryptophan--tRNA ligase, cytoplasmic isoform 2

See identical proteins and their annotated locations for NP_001157960.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AC122811, AC152061

Consensus CDS

CCDS49171.1

UniProtKB/TrEMBL

Q3U6U7, Q3UDG2

Related

ENSMUSP00000125320.2, ENSMUST00000161410.8

Conserved Domains (3) summary

PLN02486
Location:89 → 470

PLN02486; aminoacyl-tRNA ligase

TIGR00233
Location:158 → 467

trpS; tryptophanyl-tRNA synthetase

pfam00458
Location:16 → 68

WHEP-TRS; WHEP-TRS domain
NM_001411907.1 → NP_001398836.1 tryptophan--tRNA ligase, cytoplasmic isoform 1

Status: VALIDATED

Description

Transcript Variant: Variants 1, 4, 5, and 6 encode the same isoform (1).

Source sequence(s)

AC122811, AC152061

UniProtKB/Swiss-Prot

P32921, Q80ZY4, Q99J58, Q9DC65
NM_001411908.1 → NP_001398837.1 tryptophan--tRNA ligase, cytoplasmic isoform 1

Status: VALIDATED

Description

Transcript Variant: Variants 1, 4, 5, and 6 encode the same isoform (1).

Source sequence(s)

AC122811, AC152061

UniProtKB/Swiss-Prot

P32921, Q80ZY4, Q99J58, Q9DC65
NM_001411909.1 → NP_001398838.1 tryptophan--tRNA ligase, cytoplasmic isoform 1

Status: VALIDATED

Description

Transcript Variant: Variants 1, 4, 5, and 6 encode the same isoform (1).

Source sequence(s)

AC122811, AC152061

UniProtKB/Swiss-Prot

P32921, Q80ZY4, Q99J58, Q9DC65
NM_001411910.1 → NP_001398839.1 tryptophan--tRNA ligase, cytoplasmic isoform 3

Status: VALIDATED

Source sequence(s)

AC122811, AC152061
NM_011710.4 → NP_035840.3 tryptophan--tRNA ligase, cytoplasmic isoform 1

See identical proteins and their annotated locations for NP_035840.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4, 5, and 6 encode the same isoform.

Source sequence(s)

AC122811, AC152061

Consensus CDS

CCDS26166.1

UniProtKB/Swiss-Prot

P32921, Q80ZY4, Q99J58, Q9DC65

UniProtKB/TrEMBL

Q4FJZ4

Related

ENSMUSP00000124625.2, ENSMUST00000161154.2

Conserved Domains (2) summary

PLN02486
Location:89 → 470

PLN02486; aminoacyl-tRNA ligase

cd00936
Location:16 → 65

WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...

RNA

NR_177976.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC122811, AC152061
NR_177977.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC122811, AC152061

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

108825956..108860095 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515819.3 → XP_006515882.1 tryptophan--tRNA ligase, cytoplasmic isoform X1

See identical proteins and their annotated locations for XP_006515882.1

UniProtKB/Swiss-Prot

P32921, Q80ZY4, Q99J58, Q9DC65

UniProtKB/TrEMBL

Q4FJZ4

Conserved Domains (2) summary

PLN02486
Location:89 → 470

PLN02486; aminoacyl-tRNA ligase

cd00936
Location:16 → 65

WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...