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    glyQ glycine--tRNA ligase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948079, updated on 3-Dec-2024

    Summary

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    Official Symbol
    glyQ
    Official Full Name
    glycine--tRNA ligase subunit alpha
    Primary source
    ECOCYC:EG10409
    Locus tag
    b3560
    See related
    ASAP:ABE-0011626
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cfcA; ECK3548; glyS(A)
    Summary
    Glycyl-tRNA synthetase (GlyRS) is a member of the family of aminoacyl-tRNA synthetases, which interpret the genetic code by covalently linking amino acids to their specific tRNA molecules. [More information is available at EcoCyc: EG10409].
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    Genomic context

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    Sequence:
    NC_000913.3 (3724407..3725318, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene glycine--tRNA ligase subunit beta Neighboring gene putative lipoprotein YsaB Neighboring gene O-acetyltransferase WecH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutation in the small (alpha) subunit of glycyl-tRNA synthetase affects amino acid activation and subunit association parameters. Toth MJ, et al. J Biol Chem, 1990 Jan 15. PMID 2295596
    2. Rapid determination of nucleotides that define tRNA(Gly) acceptor identity. McClain WH, et al. Proc Natl Acad Sci U S A, 1991 Jul 15. PMID 2068095, Free PMC Article
    3. Internal structural features of E. coli glycyl-tRNA synthetase examined by subunit polypeptide chain fusions. Toth MJ, et al. J Biol Chem, 1986 May 25. PMID 3009467
    4. Glycyl-tRNA synthetase: an oligomeric protein containing dissimilar subunits. Ostrem DL, et al. Proc Natl Acad Sci U S A, 1970 Dec. PMID 4923123, Free PMC Article
    5. Gene for Escherichia coli glycyl-tRNA synthetase has tandem subunit coding regions in the same reading frame. Keng T, et al. J Biol Chem, 1982 Nov 10. PMID 6290471

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to glycine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of glycine-tRNA ligase complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of glycine-tRNA ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of glycine-tRNA ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycine--tRNA ligase subunit alpha
    NP_418017.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3724407..3725318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418017.1 glycine--tRNA ligase subunit alpha [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418017.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EAE3
      Conserved Domains (1) summary
      PRK09348
      Location:5 → 292
      glyQ; glycyl-tRNA synthetase subunit alpha; Validated
    Nucleotide Protein
    Heading Accession and Version

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