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    RDH14 retinol dehydrogenase 14 [ Homo sapiens (human) ]

    Gene ID: 57665, updated on 27-Nov-2024

    Summary

    Official Symbol
    RDH14provided by HGNC
    Official Full Name
    retinol dehydrogenase 14provided by HGNC
    Primary source
    HGNC:HGNC:19979
    See related
    Ensembl:ENSG00000240857 MIM:616796; AllianceGenome:HGNC:19979
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAN2; SDR7C4
    Summary
    Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in osteoblast differentiation. Located in cytosol; endoplasmic reticulum; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart (RPKM 13.2), prostate (RPKM 10.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RDH14 in Genome Data Viewer
    Location:
    2p24.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (18554723..18560653, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (18586834..18592767, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (18735989..18741919, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373451 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:18513234-18513870 Neighboring gene uncharacterized LOC105373454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11195 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:18633458-18633722 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:18637372-18637948 Neighboring gene MPRA-validated peak3612 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr2:18727890-18728410 Neighboring gene Sharpr-MPRA regulatory region 12735 Neighboring gene NT5C1B-RDH14 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11196 Neighboring gene uncharacterized LOC105373456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15360 Neighboring gene RNA, U6 small nuclear 1215, pseudogene Neighboring gene 5'-nucleotidase, cytosolic IB Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:18820604-18821104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:18821105-18821605 Neighboring gene Sharpr-MPRA regulatory region 8729 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:18845994-18847193 Neighboring gene NANOG hESC enhancer GRCh37_chr2:18958528-18959297 Neighboring gene long intergenic non-protein coding RNA 1376

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    retinol dehydrogenase 14
    Names
    alcohol dehydrogenase PAN2
    pancreas protein 2
    retinol dehydrogenase 14 (all-trans and 9-cis)
    retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
    short chain dehydrogenase/reductase family 7C member 4
    NP_065956.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020905.4NP_065956.1  retinol dehydrogenase 14

      See identical proteins and their annotated locations for NP_065956.1

      Status: VALIDATED

      Source sequence(s)
      AK314994, AY358511, CD676669
      Consensus CDS
      CCDS1693.1
      UniProtKB/Swiss-Prot
      Q9HBH5
      UniProtKB/TrEMBL
      Q53RX3
      Related
      ENSP00000370648.3, ENST00000381249.4
      Conserved Domains (1) summary
      cd09807
      Location:43328
      retinol-DH_like_SDR_c; retinol dehydrogenases (retinol-DHs), classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      18554723..18560653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      18586834..18592767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)