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    Sash3 SAM and SH3 domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317578, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sash3provided by RGD
    Official Full Name
    SAM and SH3 domain containing 3provided by RGD
    Primary source
    RGD:1560293
    See related
    EnsemblRapid:ENSRNOG00000004409 AllianceGenome:RGD:1560293
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560293
    Summary
    Predicted to be involved in several processes, including positive regulation of B cell proliferation; positive regulation of adaptive immune response; and positive regulation of immunoglobulin production. Predicted to act upstream of or within several processes, including positive regulation of T cell activation; positive regulation of cytokine production; and positive regulation of organ growth. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SASH3 (SAM and SH3 domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 620.8), Spleen (RPKM 372.0) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sash3 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (132204717..132219421)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (127326815..127341521)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (134979637..134994351)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484146 Neighboring gene apelin Neighboring gene X-prolyl aminopeptidase 2 Neighboring gene zinc finger DHHC-type palmitoyltransferase 9 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Impaired immune responses and prolonged allograft survival in Sly1 mutant mice. Beer S, et al. Mol Cell Biol, 2005 Nov. PMID 16227612, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC189506

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of CD4-positive, alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of immunoglobulin production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of immunoglobulin production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-4 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of lymphocyte activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of organ growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SAM and SH3 domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134992.1 → NP_001128464.1  SAM and SH3 domain-containing protein 3

      See identical proteins and their annotated locations for NP_001128464.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169091
      UniProtKB/TrEMBL
      B5DFK2
      Conserved Domains (4) summary
      smart00454
      Location:252 → 316
      SAM; Sterile alpha motif
      cd11968
      Location:176 → 231
      SH3_SASH3; Src homology 3 domain of Sam And SH3 Domain Containing Protein 3
      pfam12485
      Location:21 → 174
      SLY; Lymphocyte signaling adaptor protein
      cl15755
      Location:250 → 317
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      132204717..132219421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257530.5 → XP_006257592.1  SAM and SH3 domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      F7EM42
      Related
      ENSRNOP00000006035.5, ENSRNOT00000006035.7
      Conserved Domains (4) summary
      smart00454
      Location:252 → 316
      SAM; Sterile alpha motif
      cd11968
      Location:176 → 231
      SH3_SASH3; Src homology 3 domain of Sam And SH3 Domain Containing Protein 3
      pfam12485
      Location:21 → 174
      SLY; Lymphocyte signaling adaptor protein
      cl15755
      Location:250 → 317
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein Strain
    Heading Accession and Version

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