U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Asl argininosuccinate lyase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59085, updated on 4-Jan-2025

    Summary

    Official Symbol
    Aslprovided by RGD
    Official Full Name
    argininosuccinate lyaseprovided by RGD
    Primary source
    RGD:619974
    See related
    EnsemblRapid:ENSRNOG00000000903 AllianceGenome:RGD:619974
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables argininosuccinate lyase activity. Involved in several processes, including argininosuccinate metabolic process; cellular response to cAMP; and cellular response to cytokine stimulus. Located in several cellular components, including cell body fiber; mitochondrial outer membrane; and perikaryon. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 1197.6), Kidney (RPKM 605.5) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Asl in Genome Data Viewer
    Location:
    12q12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (32295779..32313257)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (26659664..26677136)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (30160922..30178348)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 7 Neighboring gene tyrosylprotein sulfotransferase 1 Neighboring gene CGRP receptor component Neighboring gene small nucleolar RNA SNORA17 Neighboring gene transfer RNA threonine (anticodon AGU) 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables argininosuccinate lyase activity  
    enables argininosuccinate lyase activity PubMed 
    enables argininosuccinate lyase activity  
    enables argininosuccinate lyase activity  
    enables identical protein binding  
    Items 1 - 25 of 43
    Process Evidence Code Pubs
    involved_in L-arginine biosynthetic process  
    involved_in L-arginine biosynthetic process  
    involved_in L-arginine biosynthetic process  
    involved_in L-arginine biosynthetic process PubMed 
    acts_upstream_of_or_within amino acid metabolic process  
    involved_in ammonia assimilation cycle  
    acts_upstream_of_or_within ammonia assimilation cycle  
    involved_in arginine biosynthetic process via ornithine  
    involved_in arginine biosynthetic process via ornithine  
    involved_in arginine metabolic process  
    involved_in argininosuccinate metabolic process PubMed 
    involved_in cellular response to ammonium ion PubMed 
    involved_in cellular response to cAMP PubMed 
    involved_in cellular response to dexamethasone stimulus PubMed 
    involved_in cellular response to glucagon stimulus PubMed 
    involved_in cellular response to glucocorticoid stimulus PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to tumor necrosis factor PubMed 
    involved_in cellular response to type II interferon PubMed 
    involved_in diaphragm development PubMed 
    involved_in kidney development PubMed 
    involved_in liver development PubMed 
    involved_in liver development PubMed 
    involved_in locomotory behavior  
    acts_upstream_of_or_within locomotory behavior  
    involved_in midgut development PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in post-embryonic development  
    acts_upstream_of_or_within post-embryonic development  
    involved_in response to amine PubMed 
    involved_in response to growth hormone PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to nutrient PubMed 
    involved_in response to peptide hormone PubMed 
    involved_in response to steroid hormone PubMed 
    involved_in response to toxic substance PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in response to zinc ion PubMed 
    involved_in urea cycle PubMed 
    involved_in urea cycle  
    involved_in urea cycle PubMed 
    Items 1 - 25 of 43
    Component Evidence Code Pubs
    located_in cell body fiber PubMed 
    is_active_in cytosol  
    located_in mitochondrial outer membrane PubMed 
    located_in neuronal cell body PubMed 
    located_in perikaryon PubMed 
    located_in perinuclear region of cytoplasm PubMed 

    General protein information

    Preferred Names
    argininosuccinate lyase
    Names
    ASAL
    arginosuccinase
    NP_067588.2
    XP_006249307.1
    XP_038945643.1
    XP_063127677.1
    XP_063127678.1
    XP_063127679.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021577.3NP_067588.2  argininosuccinate lyase

      See identical proteins and their annotated locations for NP_067588.2

      Status: PROVISIONAL

      Source sequence(s)
      BC097270
      UniProtKB/Swiss-Prot
      P20673, Q6AZ85
      UniProtKB/TrEMBL
      A0A8I6ARJ8, A0A8J8XG16, A6J0N5, Q4QRB8, Z4YND9
      Related
      ENSRNOP00000089055.1, ENSRNOT00000110317.2
      Conserved Domains (1) summary
      cd01359
      Location:27459
      Argininosuccinate_lyase; Argininosuccinate lyase (argininosuccinase, ASAL)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      32295779..32313257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271607.1XP_063127677.1  argininosuccinate lyase isoform X1

      UniProtKB/Swiss-Prot
      P20673, Q6AZ85
      UniProtKB/TrEMBL
      A0A8I6ARJ8, A0A8J8XG16, A6J0N5, Q4QRB8, Z4YND9
      Related
      ENSRNOP00000001211.8, ENSRNOT00000001211.9
    2. XM_006249245.4XP_006249307.1  argininosuccinate lyase isoform X1

      See identical proteins and their annotated locations for XP_006249307.1

      UniProtKB/Swiss-Prot
      P20673, Q6AZ85
      UniProtKB/TrEMBL
      A0A8I6ARJ8, A0A8J8XG16, A6J0N5, Q4QRB8, Z4YND9
      Conserved Domains (1) summary
      cd01359
      Location:27459
      Argininosuccinate_lyase; Argininosuccinate lyase (argininosuccinase, ASAL)
    3. XM_063271608.1XP_063127678.1  argininosuccinate lyase isoform X1

      UniProtKB/Swiss-Prot
      P20673, Q6AZ85
      UniProtKB/TrEMBL
      A0A8I6ARJ8, A0A8J8XG16, A6J0N5, Q4QRB8, Z4YND9
    4. XM_039089715.2XP_038945643.1  argininosuccinate lyase isoform X1

      UniProtKB/Swiss-Prot
      P20673, Q6AZ85
      UniProtKB/TrEMBL
      A0A8I6ARJ8, A0A8J8XG16, A6J0N5, Q4QRB8, Z4YND9
      Conserved Domains (1) summary
      cd01359
      Location:27459
      Argininosuccinate_lyase; Argininosuccinate lyase (argininosuccinase, ASAL)
    5. XM_063271609.1XP_063127679.1  argininosuccinate lyase isoform X1

      UniProtKB/Swiss-Prot
      P20673, Q6AZ85
      UniProtKB/TrEMBL
      A0A8I6ARJ8, A0A8J8XG16, A6J0N5, Q4QRB8, Z4YND9
    External link. Please review our privacy policy.