U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    OSBP oxysterol binding protein [ Homo sapiens (human) ]

    Gene ID: 5007, updated on 27-Nov-2024

    Summary

    Official Symbol
    OSBPprovided by HGNC
    Official Full Name
    oxysterol binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:8503
    See related
    Ensembl:ENSG00000110048 MIM:167040; AllianceGenome:HGNC:8503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OSBP1
    Summary
    Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in adrenal (RPKM 22.9), kidney (RPKM 22.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See OSBP in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (59574398..59615774, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (59525317..59566697, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (59341871..59383247, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723575 Neighboring gene tRNA-Lys (anticodon TTT) 3-4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:59332897-59333398 Neighboring gene long intergenic non-protein coding RNA 2739 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:59333399-59333898 Neighboring gene tRNA-Phe (anticodon GAA) 2-1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:59343523-59344722 Neighboring gene microRNA 3162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3366 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3367 Neighboring gene uncharacterized LOC101927226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4758 Neighboring gene PAT1 homolog 1, processing body mRNA decay factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3368

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables oxysterol binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sterol transfer activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sterol transfer activity TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    oxysterol-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002556.3NP_002547.1  oxysterol-binding protein 1

      See identical proteins and their annotated locations for NP_002547.1

      Status: REVIEWED

      Source sequence(s)
      AF185696, AP000442
      Consensus CDS
      CCDS7974.1
      UniProtKB/Swiss-Prot
      P22059, Q6P524
      Related
      ENSP00000263847.1, ENST00000263847.6
      Conserved Domains (3) summary
      cd13284
      Location:91189
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam00169
      Location:91181
      PH; PH domain
      pfam01237
      Location:418787
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      59574398..59615774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      59525317..59566697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)