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    Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C [ Mus musculus (house mouse) ]

    Gene ID: 20702, updated on 27-Nov-2024

    Summary

    Official Symbol
    Serpina1cprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade A, member 1Cprovided by MGI
    Primary source
    MGI:MGI:891969
    See related
    Ensembl:ENSMUSG00000079015 AllianceGenome:MGI:891969
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pi3; Pi6; Wap3; Skalp; Spi1-3; Spi1-6
    Summary
    Predicted to enable identical protein binding activity; protease binding activity; and serine-type endopeptidase inhibitor activity. Acts upstream of or within response to cytokine and response to peptide hormone. Located in extracellular region. Is expressed in gut; liver lobe; and metanephros. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; artery disease (multiple); chronic obstructive pulmonary disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human SERPINA1 (serpin family A member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 7410.2), liver E18 (RPKM 2163.4) and 2 other tissues See more
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    Genomic context

    See Serpina1c in Genome Data Viewer
    Location:
    12 E; 12 52.98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103861185..103871209, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103894926..103904950, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 1A Neighboring gene serine (or cysteine) preptidase inhibitor, clade A, member 1B pseudogene Neighboring gene serine (or cysteine) preptidase inhibitor, clade A, member 1B pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 1E

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in response to chromate ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to cytokine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to lead ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to methanol ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to peptide hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alpha-1-antitrypsin 1-3
    Names
    alpha-1 protease inhibitor 3
    alpha-1 protease inhibitor 6
    alpha-1-antitrypsin 1-6
    apha-1 protease inhibitor 3
    pre-elafin
    serine (or cysteine) proteinase inhibitor, clade A, member 1c
    serine protease inhibitor 1-3
    serine protease inhibitor 1-6
    serine protease inhibitor A1c
    serpin A1c
    trappin-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009245.2NP_033271.1  alpha-1-antitrypsin 1-3 precursor

      See identical proteins and their annotated locations for NP_033271.1

      Status: VALIDATED

      Source sequence(s)
      AC134902, M75720
      Consensus CDS
      CCDS26141.1
      UniProtKB/Swiss-Prot
      P81105, Q00896, Q91V74, Q91WH5, Q91XC1
      UniProtKB/TrEMBL
      A0A0R4J0X5
      Related
      ENSMUSP00000073695.6, ENSMUST00000074051.6
      Conserved Domains (1) summary
      smart00093
      Location:53410
      SERPIN; SERine Proteinase INhibitors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103861185..103871209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)