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    Fam89b family with sequence similarity 89, member B [ Mus musculus (house mouse) ]

    Gene ID: 17826, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fam89bprovided by MGI
    Official Full Name
    family with sequence similarity 89, member Bprovided by MGI
    Primary source
    MGI:MGI:106595
    See related
    Ensembl:ENSMUSG00000024939 AllianceGenome:MGI:106595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MMTV; Mtvr2; 1110021A21Rik
    Summary
    Enables transcription corepressor binding activity. Involved in establishment of cell polarity; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and positive regulation of cell migration. Located in cytoplasm and lamellipodium. Is expressed in several structures, including branchial arch; heart valve; liver; nervous system; and sensory organ. Orthologous to human FAM89B (family with sequence similarity 89 member B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 186.5), ovary adult (RPKM 160.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam89b in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5778115..5779694, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5728087..5729666, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene pecanex homolog 3 Neighboring gene STARR-positive B cell enhancer ABC_E4259 Neighboring gene STARR-positive B cell enhancer ABC_E11012 Neighboring gene mitogen-activated protein kinase kinase kinase 11 Neighboring gene potassium channel, subfamily K, member 7 Neighboring gene EH domain binding protein 1-like 1 Neighboring gene zinc ribbon domain containing 2 Neighboring gene latent transforming growth factor beta binding protein 3 Neighboring gene SCY1-like 1 (S. cerevisiae)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential. Cordero A, et al. J Mammary Gland Biol Neoplasia, 2023 Feb 18. PMID 36808257, Free PMC Article
    2. Novel related cDNAs (C184L, C184M, and C184S) from developing mouse brain encoding two apparently unrelated proteins. Sakuma-Takagi M, et al. Biochem Biophys Res Commun, 1999 Oct 5. PMID 10512749
    3. The Ski-binding protein C184M negatively regulates tumor growth factor-beta signaling by sequestering the Smad proteins in the cytoplasm. Kokura K, et al. J Biol Chem, 2003 May 30. PMID 12646588
    4. Identification of human homologues of the mouse mammary tumor virus receptor. Stewart AF. Arch Virol, 2002 Mar. PMID 11958456
    5. A novel membrane protein is a mouse mammary tumor virus receptor. Golovkina TV, et al. J Virol, 1998 Apr. PMID 9525630, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential.
      Title: Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Potential readthrough

    Included gene: Znrd2

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of SMAD protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine repeat adapter protein 25
    Names
    C184L ORF2 protein
    C184M protein
    MMTV receptor
    mammary tumor virus receptor 2
    protein FAM89B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023166.2 → NP_075655.2  leucine repeat adapter protein 25 isoform 2

      See identical proteins and their annotated locations for NP_075655.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      BC056166, CJ132526
      Consensus CDS
      CCDS50361.1
      UniProtKB/TrEMBL
      Q7TMI7
      Related
      ENSMUSP00000124294.2, ENSMUST00000161368.2

    2. NM_181452.2 → NP_852117.2  leucine repeat adapter protein 25 isoform 1

      See identical proteins and their annotated locations for NP_852117.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC056166, BM942073, CJ132526
      Consensus CDS
      CCDS37890.1
      UniProtKB/Swiss-Prot
      Q8K2S5, Q9JHD8, Q9JL54, Q9QUI1
      Related
      ENSMUSP00000097538.4, ENSMUST00000099955.4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5778115..5779694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QUI1.1 GenPept UniProtKB/Swiss-Prot:Q9QUI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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