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    Sfxn5 sideroflexin 5 [ Mus musculus (house mouse) ]

    Gene ID: 94282, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sfxn5provided by MGI
    Official Full Name
    sideroflexin 5provided by MGI
    Primary source
    MGI:MGI:2137681
    See related
    Ensembl:ENSMUSG00000033720 AllianceGenome:MGI:2137681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C230001H08Rik
    Summary
    Predicted to enable citrate transmembrane transporter activity. Involved in positive regulation of cold-induced thermogenesis. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and spinal cord. Orthologous to human SFXN5 (sideroflexin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 29.0), frontal lobe adult (RPKM 25.7) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sfxn5 in Genome Data Viewer
    Location:
    6 C3; 6 37.23 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85190031..85310488, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85213049..85333482, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53291 Neighboring gene empty spiracles homeobox 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:85187210-85187411 Neighboring gene STARR-seq mESC enhancer starr_16498 Neighboring gene STARR-positive B cell enhancer ABC_E4838 Neighboring gene STARR-positive B cell enhancer ABC_E10387 Neighboring gene RAB11 family interacting protein 5 (class I) Neighboring gene microRNA 705 Neighboring gene RIKEN cDNA 4933423K11 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Architecture of the outbred brown fat proteome defines regulators of metabolic physiology. Xiao H, et al. Cell, 2022 Nov 23. PMID 36334589, Free PMC Article
    2. The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3. Lockhart PJ, et al. Gene, 2002 Feb 20. PMID 12039050
    3. Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. Demangel C, et al. Eur J Immunol, 2002 Apr. PMID 11920565
    4. Identification of the mammalian Not gene via a phylogenomic approach. Plouhinec JL, et al. Gene Expr Patterns, 2004 Nov. PMID 15533813
    5. A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Fleming MD, et al. Genes Dev, 2001 Mar 15. PMID 11274051, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables citrate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables citrate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in citrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in citrate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sideroflexin-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178639.4 → NP_848754.1  sideroflexin-5

      See identical proteins and their annotated locations for NP_848754.1

      Status: VALIDATED

      Source sequence(s)
      AK036285, AK082073, BB628882, BC099507
      Consensus CDS
      CCDS20291.1
      UniProtKB/Swiss-Prot
      Q8BGG3, Q925N0
      UniProtKB/TrEMBL
      Q8BRQ9
      Related
      ENSMUSP00000041872.6, ENSMUST00000045846.12
      Conserved Domains (1) summary
      pfam03820
      Location:34 → 342
      Mtc; Tricarboxylate carrier

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      85190031..85310488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152414.1 → XP_036008307.1  sideroflexin-5 isoform X3

      Conserved Domains (1) summary
      pfam03820
      Location:29 → 214
      Mtc; Tricarboxylate carrier

    2. XM_006506816.5 → XP_006506879.1  sideroflexin-5 isoform X1

      Conserved Domains (1) summary
      pfam03820
      Location:34 → 362
      Mtc; Tricarboxylate carrier

    3. XM_030255684.1 → XP_030111544.1  sideroflexin-5 isoform X2

      Conserved Domains (1) summary
      pfam03820
      Location:1 → 256
      Mtc; Tricarboxylate carrier
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925N0.2 GenPept UniProtKB/Swiss-Prot:Q925N0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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