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    Zfp280d zinc finger protein 280D [ Mus musculus (house mouse) ]

    Gene ID: 235469, updated on 27-Nov-2024

    Summary

    Official Symbol
    Zfp280dprovided by MGI
    Official Full Name
    zinc finger protein 280Dprovided by MGI
    Primary source
    MGI:MGI:2384583
    See related
    Ensembl:ENSMUSG00000038535 AllianceGenome:MGI:2384583
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Suhw4; ZNF634; Znf280d; A930005F02Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in early conceptus; nervous system; olfactory epithelium; oocyte; and retina. Orthologous to human ZNF280D (zinc finger protein 280D). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 9.8), CNS E14 (RPKM 9.7) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zfp280d in Genome Data Viewer
    Location:
    9 D; 9 40.08 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (72181900..72271061)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (72274618..72363779)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 27188 Neighboring gene STARR-seq mESC enhancer starr_24588 Neighboring gene STARR-seq mESC enhancer starr_24589 Neighboring gene STARR-seq mESC enhancer starr_24590 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:72123162-72123349 Neighboring gene predicted gene, 25163 Neighboring gene STARR-seq mESC enhancer starr_24593 Neighboring gene ribosomal protein L27A pseudogene Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_24594 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:72238180-72238457 Neighboring gene predicted gene 27230 Neighboring gene cDNA sequence BC065403 Neighboring gene STARR-positive B cell enhancer mm9_chr9:72286185-72286486 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:72297295-72297404 Neighboring gene STARR-positive B cell enhancer ABC_E5084 Neighboring gene meiosis-specific nuclear structural protein 1 Neighboring gene testis expressed gene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC36902

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 280D
    Names
    suppressor of hairy wing homolog 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311105.1NP_001298034.1  zinc finger protein 280D isoform 2

      See identical proteins and their annotated locations for NP_001298034.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in a frame-shift compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK045173, AK146597, BB616601, BC079878, CT025608
      Consensus CDS
      CCDS81035.1
      UniProtKB/TrEMBL
      Q3TEI2, V9GXP2
      Related
      ENSMUSP00000139250.2, ENSMUST00000183410.8
      Conserved Domains (2) summary
      sd00017
      Location:372393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:57241
      DUF4195; Domain of unknown function (DUF4195)
    2. NM_146224.5NP_666336.3  zinc finger protein 280D isoform 1

      See identical proteins and their annotated locations for NP_666336.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK146597, BB616601, BC079878, CT025608
      Consensus CDS
      CCDS40683.1
      UniProtKB/Swiss-Prot
      Q3T9B1, Q68FE8, Q8BI82
      Related
      ENSMUSP00000096175.3, ENSMUST00000098576.10
      Conserved Domains (3) summary
      sd00017
      Location:372393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:335369
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:57241
      DUF4195; Domain of unknown function (DUF4195)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      72181900..72271061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511121.4XP_006511184.1  zinc finger protein 280D isoform X2

      UniProtKB/TrEMBL
      Q3TEI2
      Conserved Domains (2) summary
      sd00017
      Location:372393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:57236
      DUF4195; Domain of unknown function (DUF4195)
    2. XM_006511122.3XP_006511185.1  zinc finger protein 280D isoform X3

      UniProtKB/TrEMBL
      Q3TEI2
      Related
      ENSMUSP00000138970.2, ENSMUST00000184517.8
      Conserved Domains (2) summary
      sd00017
      Location:372393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:57236
      DUF4195; Domain of unknown function (DUF4195)
    3. XM_036154909.1XP_036010802.1  zinc finger protein 280D isoform X4

      Conserved Domains (1) summary
      sd00017
      Location:132153
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. XM_017313342.2XP_017168831.1  zinc finger protein 280D isoform X1

      UniProtKB/TrEMBL
      V9GWW1
      Related
      ENSMUSP00000138857.2, ENSMUST00000184036.8
      Conserved Domains (3) summary
      sd00017
      Location:347368
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:310344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:32211
      DUF4195; Domain of unknown function (DUF4195)
    5. XM_017313343.2XP_017168832.1  zinc finger protein 280D isoform X5

      Conserved Domains (1) summary
      sd00017
      Location:102123
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. XM_030244338.1XP_030100198.1  zinc finger protein 280D isoform X4

      Conserved Domains (1) summary
      sd00017
      Location:132153
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. XR_004935419.1 RNA Sequence

    2. XR_004935420.1 RNA Sequence

    3. XR_004935421.1 RNA Sequence