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    Grk5 G protein-coupled receptor kinase 5 [ Mus musculus (house mouse) ]

    Gene ID: 14773, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Grk5provided by MGI
    Official Full Name
    G protein-coupled receptor kinase 5provided by MGI
    Primary source
    MGI:MGI:109161
    See related
    Ensembl:ENSMUSG00000003228 AllianceGenome:MGI:109161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gprk5
    Summary
    Predicted to enable beta-adrenergic receptor kinase activity and protein serine/threonine kinase activity. Involved in fat cell differentiation. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human GRK5 (G protein-coupled receptor kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 3.7), subcutaneous fat pad adult (RPKM 2.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Grk5 in Genome Data Viewer
    Location:
    19 D3; 19 56.52 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (60877995..61084406)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (60889560..61095968)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene sideroflexin 4 Neighboring gene STARR-positive B cell enhancer ABC_E7678 Neighboring gene STARR-positive B cell enhancer ABC_E11681 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60965501-60965802 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60965940-60966241 Neighboring gene peroxiredoxin 3 Neighboring gene predicted gene 9529 Neighboring gene predicted gene, 22520 Neighboring gene zinc finger protein 950 Neighboring gene STARR-positive B cell enhancer ABC_E10001 Neighboring gene STARR-positive B cell enhancer ABC_E9458 Neighboring gene STARR-positive B cell enhancer ABC_E7681 Neighboring gene STARR-positive B cell enhancer ABC_E1214 Neighboring gene STARR-seq mESC enhancer starr_46603 Neighboring gene STARR-seq mESC enhancer starr_46604 Neighboring gene ribosomal protein S25 pseudogene Neighboring gene predicted gene 6020 Neighboring gene predicted gene, 22365

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling. Keys JR, et al. Circulation, 2005 Aug 23. PMID 16103237
    2. G-protein-coupled receptor kinase-5 mediates inflammation but does not regulate cellular infiltration or bacterial load in a polymicrobial sepsis model in mice. Packiriswamy N, et al. J Innate Immun, 2013. PMID 23485819, Free PMC Article
    3. GRK5 ablation contributes to insulin resistance. Wang L, et al. Biochem Biophys Res Commun, 2012 Dec 7. PMID 23111327
    4. Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication. Gold JI, et al. Circ Res, 2012 Sep 28. PMID 22859683, Free PMC Article
    5. GRK5 deficiency leads to susceptibility to intermittent hypoxia-induced cognitive impairment. Singh P, et al. Behav Brain Res, 2016 Apr 1. PMID 26778781, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Irg1 regulates bone homeostasis via regulating the Grk5 expression.
      Title: Irg1 regulates bone homeostasis via regulating the Grk5 expression.
    2. Genetic Arg-304-His substitution in GRK5 protects against sepsis progression by alleviating NF-kappaB-mediated inflammation.
      Title: Genetic Arg-304-His substitution in GRK5 protects against sepsis progression by alleviating NF-κB-mediated inflammation.
    3. GRK5-mediated inflammation and fibrosis exert cardioprotective effects during the acute phase of myocardial infarction.
      Title: GRK5-mediated inflammation and fibrosis exert cardioprotective effects during the acute phase of myocardial infarction.
    4. G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure.
      Title: G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure.
    5. A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure.
      Title: A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure.
    6. GRK5 is a regulator of fibroblast activation and cardiac fibrosis.
      Title: GRK5 is a regulator of fibroblast activation and cardiac fibrosis.
    7. GRK5 Controls SAP97-Dependent Cardiotoxic beta1 Adrenergic Receptor-CaMKII Signaling in Heart Failure.
      Title: GRK5 Controls SAP97-Dependent Cardiotoxic β(1) Adrenergic Receptor-CaMKII Signaling in Heart Failure.
    8. GRK5 deficiency contributes to the pathogenesis of Alzheimer's disease by influencing the hyperphosphorylation of tau through the activation of GSK3beta.
      Title: GRK5 influences the phosphorylation of tau via GSK3β and contributes to Alzheimer's disease.
    9. These data indicate that GRK2, GRK5 and GRK6 redundantly modulate Smo-GATA crosstalk in fetal mouse hearts, orchestrating transcriptional pathways previously linked to clinical and experimental atrioventricular canal defects
      Title: G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts.
    10. GRK5 is critical for maintaining normal mTORC1 signaling and connectivity in medial prefrontal cortex and normal social behavior.
      Title: GRK5 Regulates Social Behavior Via Suppression of mTORC1 Signaling in Medial Prefrontal Cortex.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-adrenergic receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-adrenergic receptor kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in desensitization of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tachykinin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tachykinin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    G protein-coupled receptor kinase 5
    Names
    g protein-coupled receptor kinase GRK5
    NP_061357.3
    XP_006526760.1
    XP_011245451.1
    XP_017173555.2
    XP_036017332.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018869.3 → NP_061357.3  G protein-coupled receptor kinase 5

      See identical proteins and their annotated locations for NP_061357.3

      Status: VALIDATED

      Source sequence(s)
      AK135076, AK161821, AW456000, BY289760
      Consensus CDS
      CCDS29945.1
      UniProtKB/Swiss-Prot
      O70292, O70297, Q8VEB1
      UniProtKB/TrEMBL
      Q3TST4
      Related
      ENSMUSP00000003313.9, ENSMUST00000003313.10
      Conserved Domains (3) summary
      smart00220
      Location:186 → 448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05632
      Location:183 → 495
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
      cl02565
      Location:53 → 175
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      60877995..61084406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526697.5 → XP_006526760.1  G protein-coupled receptor kinase 5 isoform X1

      Conserved Domains (2) summary
      cd05632
      Location:151 → 463
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
      cl02565
      Location:21 → 143
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. XM_036161439.1 → XP_036017332.1  G protein-coupled receptor kinase 5 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:26 → 303
      PKc_like; Protein Kinases, catalytic domain

    3. XM_011247149.4 → XP_011245451.1  G protein-coupled receptor kinase 5 isoform X2

      Conserved Domains (2) summary
      cd05632
      Location:136 → 448
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
      cl02565
      Location:6 → 128
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    4. XM_017318066.3 → XP_017173555.2  G protein-coupled receptor kinase 5 isoform X4

      Conserved Domains (2) summary
      cd05632
      Location:19 → 331
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
      cl02565
      Location:1 → 19
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEB1.2 GenPept UniProtKB/Swiss-Prot:Q8VEB1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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