Sh3rf3 SH3 domain containing ring finger 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sh3rf3provided by MGI
Official Full Name: SH3 domain containing ring finger 3provided by MGI
Primary source: MGI:MGI:2444637
See related: Ensembl:ENSMUSG00000037990 AllianceGenome:MGI:2444637
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sh3md4; Sh3rf31; Igfbp5-ip; 4831416G18Rik
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of JNK cascade; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Is expressed in several structures, including central nervous system; lung; metanephros; retina; and vibrissa. Orthologous to human SH3RF3 (SH3 domain containing ring finger 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 2.4), cortex adult (RPKM 1.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 29.41 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (58649181..58974738)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (58811908..59138916)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Insulin-like growth factor binding protein 5 interacting protein (IGFBP5-IP) may act as intracellular mediator of growth promoting actions of IGFBP5 and perhaps other osteoregulatory agents in bone cells.
Title: Identification and characterization of novel IGFBP5 interacting protein: evidence IGFBP5-IP is a potential regulator of osteoblast cell proliferation.
Androgen suppressive therapy increases IGFBP5 in the bone marrow microenvironment and thereby may facilitate the progression of prostate cancer.
Title: Regulation of global gene expression in the bone marrow microenvironment by androgen: androgen ablation increases insulin-like growth factor binding protein-5 expression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit60 (e-PCR), detects polymorphism
- UniSTS:116613

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase SH3RF3

Names: SH3 domain-containing RING finger protein 3; SH3 multiple domains 4; SH3 multiple domains protein 4; insulin-like growth factor binding protein 5 interacting protein; plenty of SH3s 2

NP_766376.2

EC 2.3.2.27

XP_006513680.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172788.3 → NP_766376.2 E3 ubiquitin-protein ligase SH3RF3

See identical proteins and their annotated locations for NP_766376.2

Status: VALIDATED

Source sequence(s)

AK133071, BC057304, BF470772, CD741846

Consensus CDS

CCDS35906.2

UniProtKB/Swiss-Prot

Q3V0K8, Q3V0Q0, Q8C120

Related

ENSMUSP00000120938.2, ENSMUST00000153031.2

Conserved Domains (4) summary

cd11785
Location:823 → 877

SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains

cd11925
Location:461 → 517

SH3_SH3RF3_3; Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase

cd00162
Location:51 → 93

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl17036
Location:190 → 243

SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

58649181..58974738

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513617.4 → XP_006513680.1 E3 ubiquitin-protein ligase SH3RF3 isoform X1

Conserved Domains (3) summary

cd11785
Location:592 → 646

SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains

cd11925
Location:230 → 286

SH3_SH3RF3_3; Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase

cl17036
Location:22 → 76

SH3; Src Homology 3 domain superfamily