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    Skint1 selection and upkeep of intraepithelial T cells 1 [ Mus musculus (house mouse) ]

    Gene ID: 639781, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Skint1provided by MGI
    Official Full Name
    selection and upkeep of intraepithelial T cells 1provided by MGI
    Primary source
    MGI:MGI:3649627
    See related
    Ensembl:ENSMUSG00000089773 AllianceGenome:MGI:3649627
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Skint-1
    Summary
    Predicted to enable signaling receptor binding activity. Acts upstream of or within positive regulation of cell differentiation and positive thymic T cell selection. Located in cell periphery. Is expressed in islets of Langerhans; skin; thymus; and thymus primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Skint1 in Genome Data Viewer
    Location:
    4 D1; 4 51.53 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (111863466..111886735)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (112006269..112029538)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene selection and upkeep of intraepithelial T cells 8 Neighboring gene STARR-seq mESC enhancer starr_11097 Neighboring gene STARR-seq mESC enhancer starr_11098 Neighboring gene selection and upkeep of intraepithelial T cells 7 Neighboring gene STARR-seq mESC enhancer starr_11099 Neighboring gene selection and upkeep of intraepithelial T cells 4 Neighboring gene selection and upkeep of intraepithelial T cells 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice lacking all of the Skint family genes. Narita T, et al. Int Immunol, 2018 Jun 26. PMID 29718261
    2. Human papillomavirus oncoproteins induce a reorganization of epithelial-associated γδ T cells promoting tumor formation. Van Hede D, et al. Proc Natl Acad Sci U S A, 2017 Oct 24. PMID 29073102, Free PMC Article
    3. Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection. Salim M, et al. J Biol Chem, 2016 Apr 22. PMID 26917727, Free PMC Article
    4. The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification. Coffey F, et al. J Exp Med, 2014 Feb 10. PMID 24493796, Free PMC Article
    5. Skint-1 is a highly specific, unique selecting component for epidermal T cells. Barbee SD, et al. Proc Natl Acad Sci U S A, 2011 Feb 22. PMID 21300860, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results provide the first structural insights into the Skint family, identifying a putative receptor binding surface that directly implicates Skint-1 in receptor-ligand interactions crucial for DETC selection.
      Title: Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection.
    2. identifies a common molecular mechanism for the development of interferon-gamma-secreting versus interleukin-17-secreting gammadelta T cells
      Title: Skint-1 identifies a common molecular mechanism for the development of interferon-γ-secreting versus interleukin-17-secreting γδ T cells.
    3. transgenic Skint-1, across a broad range of transgenic Skint-1, across a broad range of expression levels, precisely and selectively determines the Vgamma5Vdelta1(+) dendritic epidermal T-cell compartment
      Title: Skint-1 is a highly specific, unique selecting component for epidermal T cells.
    4. Skint1 is the prototypic member of a rapidly evolving family of at least 11 genes in mouse, with greatest similarity to the butyrophilin genes.
      Title: Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of epithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of gamma-delta T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive thymic T cell selection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    selection and upkeep of intraepithelial T-cells protein 1
    Names
    Immunoglobulin-like and transmembrane domain-containing protein expressed in skin and thymus protein 1
    skint 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102662.1 → NP_001096132.1  selection and upkeep of intraepithelial T-cells protein 1 precursor

      See identical proteins and their annotated locations for NP_001096132.1

      Status: PROVISIONAL

      Source sequence(s)
      EF494889
      Consensus CDS
      CCDS51267.1
      UniProtKB/Swiss-Prot
      A7TZE6, A7TZE7, A7XUW2, A7XUW8, A7XUX1, A9XK90
      Related
      ENSMUSP00000124737.2, ENSMUST00000162158.2
      Conserved Domains (2) summary
      cd05713
      Location:42 → 141
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:35 → 140
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      111863466..111886735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7TZE6.1 GenPept UniProtKB/Swiss-Prot:A7TZE6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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