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    Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 14924, updated on 3-Dec-2024

    Summary

    Official Symbol
    Magi1provided by MGI
    Official Full Name
    membrane associated guanylate kinase, WW and PDZ domain containing 1provided by MGI
    Primary source
    MGI:MGI:1203522
    See related
    Ensembl:ENSMUSG00000045095 AllianceGenome:MGI:1203522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AIP3; BAP1; WWP3; Baiap1; Gukmi1; MAGI1c; Magi-1; TNRC19; mKIAA4129
    Summary
    Predicted to enable alpha-actinin binding activity. Involved in endothelial cell morphogenesis. Located in several cellular components, including adherens junction; cytoplasm; and nucleus. Is expressed in several structures, including facial prominence; genitourinary system; liver; musculoskeletal system; and spleen. Orthologous to human MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E14 (RPKM 9.8), whole brain E14.5 (RPKM 9.3) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Magi1 in Genome Data Viewer
    Location:
    6 D1; 6 42.7 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (93652434..94260906, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (93675453..94283929, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22312 Neighboring gene STARR-seq mESC enhancer starr_16685 Neighboring gene STARR-seq mESC enhancer starr_16686 Neighboring gene STARR-seq mESC enhancer starr_16687 Neighboring gene STARR-seq mESC enhancer starr_16688 Neighboring gene ribosomal protein P0 pseudogene Neighboring gene predicted gene, 53322 Neighboring gene VISTA enhancer mm1316 Neighboring gene STARR-seq mESC enhancer starr_16692 Neighboring gene predicted gene, 23035 Neighboring gene predicted gene, 22840 Neighboring gene STARR-seq mESC enhancer starr_16697 Neighboring gene STARR-seq mESC enhancer starr_16699 Neighboring gene RIKEN cDNA 4930511A08 gene Neighboring gene STARR-seq mESC enhancer starr_16702 Neighboring gene STARR-seq mESC enhancer starr_16704 Neighboring gene predicted gene, 31661 Neighboring gene predicted gene, 19908

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA4129

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables alpha-actinin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in endothelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
    Names
    BAI1-associated protein 1
    membrane-associated guanylate kinase inverted 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029850.5NP_001025021.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform c

      See identical proteins and their annotated locations for NP_001025021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (c).
      Source sequence(s)
      AC138381, AC153601, AC162382
      Consensus CDS
      CCDS20377.1
      UniProtKB/Swiss-Prot
      O54893, O54894, O54895, Q6RHR9
      UniProtKB/TrEMBL
      B9EKC0
      Related
      ENSMUSP00000086730.6, ENSMUST00000089317.12
      Conserved Domains (6) summary
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11321214
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9881071
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361390
      WW; WW domain
      pfam16666
      Location:714797
      MAGI_u5; Unstructured region on MAGI
    2. NM_001083320.3NP_001076789.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon structure and has multiple differences in the coding region, compared to variant 3. It encodes isoform b, which is shorter than isoform c.
      Source sequence(s)
      AC138381, AC153601
      Consensus CDS
      CCDS39573.1
      UniProtKB/TrEMBL
      E9PZ12, Q5DTM1
      Related
      ENSMUSP00000091283.6, ENSMUST00000093769.8
      Conserved Domains (7) summary
      smart00456
      Location:134165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:916998
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:9741223
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:760855
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75104
      WW; WW domain
      pfam16663
      Location:134
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:489570
      MAGI_u5; Unstructured region on MAGI
    3. NM_001083321.3NP_001076790.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 3. These differences cause translation initiation at a downstream start codon and result in a different 3' coding region and 3' UTR, compared to variant 3. It encodes isoform d, which is shorter and has a distinct C-terminus, compared to isoform c. Variants 1, 27, and 29 all encode the same isoform (d).
      Source sequence(s)
      AC138381, AC153601
      Consensus CDS
      CCDS85098.1
      UniProtKB/TrEMBL
      A0A0N4SWH0, Q5DTM1
      Related
      ENSMUSP00000145515.2, ENSMUST00000203688.3
      Conserved Domains (6) summary
      smart00456
      Location:134165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:916998
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:76105
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:761855
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16663
      Location:134
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:487570
      MAGI_u5; Unstructured region on MAGI
    4. NM_001286784.2NP_001273713.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform e

      See identical proteins and their annotated locations for NP_001273713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. It encodes isoform e, which is shorter than isoform c.
      Source sequence(s)
      AC138381, AC153601, AC162382
      UniProtKB/TrEMBL
      B9EKC0, Q4H4B4
      Conserved Domains (6) summary
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11311213
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9761070
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:349378
      WW; WW domain
      pfam16666
      Location:702785
      MAGI_u5; Unstructured region on MAGI
    5. NM_001286785.2NP_001273714.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site and includes an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 3. It encodes isoform f, which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AC138381, AC153601, AC162382
      Consensus CDS
      CCDS85099.1
      UniProtKB/TrEMBL
      A0A0N4SUZ0, B9EKC0
      Related
      ENSMUSP00000144881.2, ENSMUST00000204347.3
      Conserved Domains (6) summary
      smart00456
      Location:361392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11441226
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9881083
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:714797
      MAGI_u5; Unstructured region on MAGI
    6. NM_001286786.2NP_001273715.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform g

      See identical proteins and their annotated locations for NP_001273715.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) contains multiple coding region differences compared to variant 3, and its 3' terminal exon extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform g, which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AC138381, AC153601, AC162382
      UniProtKB/TrEMBL
      B9EKC0, Q4H4B5
      Conserved Domains (6) summary
      smart00456
      Location:349380
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11311213
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9761070
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:702785
      MAGI_u5; Unstructured region on MAGI
    7. NM_001286788.2NP_001273717.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) has multiple differences, compared to variant 3. These differences cause translation initiation at a downstream start codon and result in a different 3' coding region and 3' UTR, compared to variant 3. It encodes isoform h, which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (6) summary
      smart00456
      Location:134165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:914996
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:76105
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:759853
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16663
      Location:134
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:487570
      MAGI_u5; Unstructured region on MAGI
    8. NM_001409967.1NP_001396896.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601, AC162382
      UniProtKB/TrEMBL
      B9EKC0
    9. NM_001409968.1NP_001396897.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601, AC162382
      UniProtKB/TrEMBL
      Q4VBG2
    10. NM_001409969.1NP_001396898.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    11. NM_001409970.1NP_001396899.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    12. NM_001409971.1NP_001396900.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform m

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    13. NM_001409972.1NP_001396901.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform n

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    14. NM_001409973.1NP_001396902.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform o

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601, AC162382
      UniProtKB/TrEMBL
      B9EKC0
      Related
      ENSMUSP00000145244.2, ENSMUST00000203519.3
    15. NM_001409974.1NP_001396903.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform p

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    16. NM_001409975.1NP_001396904.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform q

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    17. NM_001409976.1NP_001396905.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform r

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    18. NM_001409978.1NP_001396907.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform s

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    19. NM_001409979.1NP_001396908.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform t

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    20. NM_001409980.1NP_001396909.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform u

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    21. NM_001409982.1NP_001396911.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform v

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    22. NM_001409983.1NP_001396912.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform v

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    23. NM_001409984.1NP_001396913.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform w

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    24. NM_001409985.1NP_001396914.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform v

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    25. NM_001409986.1NP_001396915.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      A0A0N4SWH0, Q5DTM1
    26. NM_001409987.1NP_001396916.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform x

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    27. NM_001409988.1NP_001396917.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      A0A0N4SWH0, Q5DTM1
    28. NM_001409989.1NP_001396918.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform x

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    29. NM_001409990.1NP_001396919.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform y

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    30. NM_001409991.1NP_001396920.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform z

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
    31. NM_010367.4NP_034497.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_034497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains multiple coding region differences, one of which results in a frameshift and an early stop codon, compared to variant 3. It encodes isoform a, which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AC138381, AC153601, AC162382
      Consensus CDS
      CCDS20378.1
      UniProtKB/TrEMBL
      A0A0R4J0S6, Q4VBG2
      Related
      ENSMUSP00000062085.9, ENSMUST00000055224.15
      Conserved Domains (6) summary
      smart00456
      Location:349380
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:10351117
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:798873
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:702784
      MAGI_u5; Unstructured region on MAGI

    RNA

    1. NR_104594.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) has multiple differences compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC138381, AC153601
      Related
      ENSMUST00000204532.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      93652434..94260906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505586.3XP_006505649.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:349380
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11321214
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:11901439
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:9761071
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:702785
      MAGI_u5; Unstructured region on MAGI
    2. XM_036165869.1XP_036021762.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X14

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:361392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:10751157
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:11331382
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:838913
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:716797
      MAGI_u5; Unstructured region on MAGI
    3. XM_006505584.3XP_006505647.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:361392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11431225
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:12011450
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:9871082
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:714796
      MAGI_u5; Unstructured region on MAGI
    4. XM_030255179.2XP_030111039.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X15

      UniProtKB/TrEMBL
      Q4VBG2
      Conserved Domains (7) summary
      smart00456
      Location:361392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:10481130
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:11061355
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:811886
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:714797
      MAGI_u5; Unstructured region on MAGI
    5. XM_006505600.3XP_006505663.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X36

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:361392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11151197
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:11731422
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:9601054
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:714797
      MAGI_u5; Unstructured region on MAGI
    6. XM_036165867.1XP_036021760.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:361392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11161198
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:11741423
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:9601055
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:716804
      MAGI_u5; Unstructured region on MAGI
    7. XM_030255186.2XP_030111046.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X32

      UniProtKB/TrEMBL
      Q4VBG2
      Conserved Domains (6) summary
      smart00456
      Location:361392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:10761158
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:839914
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:714797
      MAGI_u5; Unstructured region on MAGI
    8. XM_006505601.4XP_006505664.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X37

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:361392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11431225
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9881082
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:714797
      MAGI_u5; Unstructured region on MAGI
    9. XM_006505581.3XP_006505644.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:361392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11441226
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:12021451
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:9881083
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:714797
      MAGI_u5; Unstructured region on MAGI
    10. XM_036165868.1XP_036021761.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X13

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:10761158
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:11341383
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:839914
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:717798
      MAGI_u5; Unstructured region on MAGI
    11. XM_030255184.2XP_030111044.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11431225
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:9881082
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:715797
      MAGI_u5; Unstructured region on MAGI
    12. XM_006505583.3XP_006505646.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11441226
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:12021451
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:9881083
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:715797
      MAGI_u5; Unstructured region on MAGI
    13. XM_036165876.1XP_036021769.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X31

      UniProtKB/TrEMBL
      Q4VBG2
      Conserved Domains (6) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11051187
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:9611044
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:717805
      MAGI_u5; Unstructured region on MAGI
    14. XM_006505588.3XP_006505651.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11161198
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:11741423
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:9611055
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:715798
      MAGI_u5; Unstructured region on MAGI
    15. XM_006505587.3XP_006505650.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11171199
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:11751424
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:9611056
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:715798
      MAGI_u5; Unstructured region on MAGI
    16. XM_036165872.1XP_036021765.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X26

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11171199
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9611056
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:717805
      MAGI_u5; Unstructured region on MAGI
    17. XM_006505589.3XP_006505652.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X12

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:10771159
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:11351384
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:840915
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:715798
      MAGI_u5; Unstructured region on MAGI
    18. XM_017321400.3XP_017176889.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X30

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:10771159
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:840915
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:715798
      MAGI_u5; Unstructured region on MAGI
    19. XM_036165873.1XP_036021766.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X27

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:10771159
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:840915
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:717799
      MAGI_u5; Unstructured region on MAGI
    20. XM_006505585.3XP_006505648.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11331215
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:11911440
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:9891072
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:715798
      MAGI_u5; Unstructured region on MAGI
    21. XM_017321399.3XP_017176888.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X20

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11331215
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:9891072
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:715798
      MAGI_u5; Unstructured region on MAGI
    22. XM_006505582.3XP_006505645.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11441226
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:12021451
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:9891083
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:715798
      MAGI_u5; Unstructured region on MAGI
    23. XM_006505593.4XP_006505656.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X19

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11441226
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9891083
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:715798
      MAGI_u5; Unstructured region on MAGI
    24. XM_006505580.3XP_006505643.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11451227
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:12031452
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:9891084
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302331
      WW; WW domain
      pfam16666
      Location:715798
      MAGI_u5; Unstructured region on MAGI
    25. XM_006505592.3XP_006505655.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X18

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11451227
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9891084
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:715798
      MAGI_u5; Unstructured region on MAGI
    26. XM_006505591.3XP_006505654.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X17

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11451227
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9891084
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:715798
      MAGI_u5; Unstructured region on MAGI
    27. XM_036165874.1XP_036021767.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X29

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:122153
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:905987
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:9631212
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:749844
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75104
      WW; WW domain
      pfam16663
      Location:134
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:477559
      MAGI_u5; Unstructured region on MAGI
    28. XM_006505599.5XP_006505662.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X22

      See identical proteins and their annotated locations for XP_006505662.1

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:134165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:917999
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:9751224
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:761856
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75104
      WW; WW domain
      pfam16663
      Location:134
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:487570
      MAGI_u5; Unstructured region on MAGI
    29. XM_006505594.5XP_006505657.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X21

      See identical proteins and their annotated locations for XP_006505657.1

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:135166
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:9181000
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:9761225
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:762857
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75104
      WW; WW domain
      pfam16663
      Location:134
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:488571
      MAGI_u5; Unstructured region on MAGI
    30. XM_030255181.2XP_030111041.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X22

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:134165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:917999
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:9751224
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:761856
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75104
      WW; WW domain
      pfam16663
      Location:134
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:487570
      MAGI_u5; Unstructured region on MAGI
    31. XM_006505596.4XP_006505659.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X21

      See identical proteins and their annotated locations for XP_006505659.1

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:135166
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:9181000
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:9761225
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:762857
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75104
      WW; WW domain
      pfam16663
      Location:134
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:488571
      MAGI_u5; Unstructured region on MAGI
    32. XM_006505597.5XP_006505660.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X21

      See identical proteins and their annotated locations for XP_006505660.1

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:135166
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:9181000
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:9761225
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:762857
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75104
      WW; WW domain
      pfam16663
      Location:134
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:488571
      MAGI_u5; Unstructured region on MAGI
    33. XM_030255183.2XP_030111043.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X24

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:134165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:916998
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:9741223
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:761855
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75104
      WW; WW domain
      pfam16663
      Location:134
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:487570
      MAGI_u5; Unstructured region on MAGI
    34. XM_006505598.5XP_006505661.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X22

      See identical proteins and their annotated locations for XP_006505661.1

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:134165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:917999
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:9751224
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:761856
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75104
      WW; WW domain
      pfam16663
      Location:134
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:487570
      MAGI_u5; Unstructured region on MAGI
    35. XM_036165871.1XP_036021764.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X25

      UniProtKB/TrEMBL
      E9PZ12, Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:134165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:916998
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:9741223
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:760855
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75104
      WW; WW domain
      pfam16663
      Location:134
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:489570
      MAGI_u5; Unstructured region on MAGI