Baz1a bromodomain adjacent to zinc finger domain 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Baz1aprovided by MGI
Official Full Name: bromodomain adjacent to zinc finger domain 1Aprovided by MGI
Primary source: MGI:MGI:1309478
See related: Ensembl:ENSMUSG00000035021 AllianceGenome:MGI:1309478
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acf1; Gtl5; cbp146; Wcrf180; B930060C03
Summary: Predicted to enable DNA binding activity. Involved in positive regulation of DNA replication. Located in nuclear chromosome and pericentric heterochromatin. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human BAZ1A (bromodomain adjacent to zinc finger domain 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 10.5), liver E14 (RPKM 10.0) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C1; 12 23.84 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (54939774..55061155, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (54892989..55014371, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis.
Title: Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis.
results revealed chromatin remodeling modulator BAZ1A acting as a novel regulator of cellular senescence in both normal and cancer cells, indicating a new target for potential cancer treatment
Title: Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells.
Results from the study suggest that acute cocaine exposure increased Baz1a expression in nucleus accumbens while repeated cocaine exposure produced the opposite effect. Findings implicate BAZ1A in molecular and behavioral plasticity to cocaine and offer new insight into the pathophysiology of cocaine addiction.
Title: Regulation of BAZ1A and nucleosome positioning in the nucleus accumbens in response to cocaine.
Baz1a deficiency causes male-specific sterility in accord with its high expression in male germ cells, where it displays dynamic, stage-specific patterns of chromosomal localization.
Title: Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12Dcr2 (e-PCR), detects polymorphism
- UniSTS:507485

L29468 (e-PCR)
- UniSTS:124894

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated DNA replication	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromatin remodeling	TAS Traceable Author Statement more info	PubMed
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ACF complex	ISO Inferred from Sequence Orthology more info
part_of CHRAC	IBA Inferred from Biological aspect of Ancestor more info
part_of CHRAC	ISO Inferred from Sequence Orthology more info
part_of CHRAC	NAS Non-traceable Author Statement more info	PubMed
is_active_in nuclear chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in pericentric heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bromodomain adjacent to zinc finger domain protein 1A

Names: gene trap locus 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013815.2 → NP_038843.2 bromodomain adjacent to zinc finger domain protein 1A

See identical proteins and their annotated locations for NP_038843.2

Status: VALIDATED

Source sequence(s)

AC138767, AC154732, CT030142

Consensus CDS

CCDS56838.1

UniProtKB/Swiss-Prot

O88379, Q3TKK7, Q3UXF6

UniProtKB/TrEMBL

G3UWZ0

Related

ENSMUSP00000133478.2, ENSMUST00000173433.8

Conserved Domains (8) summary

cd05504
Location:1418 → 1531

Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...

PTZ00121
Location:643 → 795

PTZ00121; MAEBL; Provisional

cd15627
Location:1148 → 1193

PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)

pfam02791
Location:423 → 483

DDT; DDT domain

pfam05956
Location:1255 → 1437

APC_basic; APC basic domain

pfam10537
Location:23 → 122

WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal

pfam15612
Location:591 → 635

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:799 → 925

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

54939774..55061155 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515670.4 → XP_006515733.1 bromodomain adjacent to zinc finger domain protein 1A isoform X1

See identical proteins and their annotated locations for XP_006515733.1

UniProtKB/Swiss-Prot

O88379, Q3TKK7, Q3UXF6

UniProtKB/TrEMBL

G3UWZ0

Conserved Domains (8) summary

cd05504
Location:1418 → 1531

Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...

PTZ00121
Location:643 → 795

PTZ00121; MAEBL; Provisional

cd15627
Location:1148 → 1193

PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)

pfam02791
Location:423 → 483

DDT; DDT domain

pfam05956
Location:1255 → 1437

APC_basic; APC basic domain

pfam10537
Location:23 → 122

WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal

pfam15612
Location:591 → 635

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:799 → 925

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
XM_006515671.5 → XP_006515734.1 bromodomain adjacent to zinc finger domain protein 1A isoform X2

UniProtKB/Swiss-Prot

O88379, Q3TKK7, Q3UXF6

Conserved Domains (8) summary

cd05504
Location:1386 → 1499

Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...

PTZ00121
Location:611 → 763

PTZ00121; MAEBL; Provisional

cd15627
Location:1116 → 1161

PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)

pfam02791
Location:423 → 483

DDT; DDT domain

pfam05956
Location:1223 → 1405

APC_basic; APC basic domain

pfam10537
Location:23 → 122

WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal

pfam15612
Location:559 → 603

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:767 → 893

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
XM_030246647.2 → XP_030102507.1 bromodomain adjacent to zinc finger domain protein 1A isoform X4

UniProtKB/TrEMBL

Q6P1D9

Conserved Domains (6) summary

cd05504
Location:902 → 1015

Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...

PTZ00121
Location:127 → 279

PTZ00121; MAEBL; Provisional

cd15627
Location:632 → 677

PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)

pfam05956
Location:739 → 906

APC_basic; APC basic domain

pfam15612
Location:75 → 119

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:283 → 409

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
XM_030246646.2 → XP_030102506.1 bromodomain adjacent to zinc finger domain protein 1A isoform X3

UniProtKB/TrEMBL

Q6P1D9

Conserved Domains (6) summary

cd05504
Location:934 → 1047

Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...

PTZ00121
Location:159 → 311

PTZ00121; MAEBL; Provisional

cd15627
Location:664 → 709

PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)

pfam05956
Location:771 → 938

APC_basic; APC basic domain

pfam15612
Location:107 → 151

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:315 → 441

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif