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    Prickle2 prickle planar cell polarity protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 243548, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prickle2provided by MGI
    Official Full Name
    prickle planar cell polarity protein 2provided by MGI
    Primary source
    MGI:MGI:1925144
    See related
    Ensembl:ENSMUSG00000030020 AllianceGenome:MGI:1925144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pk2; mpk2; 6230400G14Rik; 6720451F06Rik
    Summary
    Predicted to enable zinc ion binding activity. Involved in several processes, including embryonic brain development; maintenance of postsynaptic density structure; and regulation of postsynaptic density assembly. Acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity. Located in apicolateral plasma membrane; cytoplasm; and lateral plasma membrane. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; primitive streak; and respiratory system. Orthologous to human PRICKLE2 (prickle planar cell polarity protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 12.7), frontal lobe adult (RPKM 12.2) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Prickle2 in Genome Data Viewer
    Location:
    6 D1; 6 41.05 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (92347876..92683233, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (92370891..92706334, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16664 Neighboring gene predicted gene, 30688 Neighboring gene predicted gene 44803 Neighboring gene thyrotropin releasing hormone Neighboring gene predicted gene, 38862 Neighboring gene STARR-seq mESC enhancer starr_16666 Neighboring gene STARR-seq mESC enhancer starr_16669 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene RNA binding motif protein 17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16670 Neighboring gene RIKEN cDNA A730049H05 gene Neighboring gene STARR-seq mESC enhancer starr_16671 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 9 Neighboring gene predicted gene, 52913 Neighboring gene STARR-seq mESC enhancer starr_16672 Neighboring gene STARR-seq mESC enhancer starr_16673

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density IEP
    Inferred from Expression Pattern
    more info
    PubMed 

    General protein information

    Preferred Names
    prickle-like protein 2
    Names
    prickle homolog 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081146.3NP_001074615.1  prickle-like protein 2 isoform a

      See identical proteins and their annotated locations for NP_001074615.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC164636, AC166101
      Consensus CDS
      CCDS39572.1
      UniProtKB/TrEMBL
      A7YQ68
      Related
      ENSMUSP00000032093.6, ENSMUST00000032093.12
      Conserved Domains (4) summary
      cd09415
      Location:186244
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:249304
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:309367
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:82178
      PET_Prickle; The PET domain of Prickle
    2. NM_001134459.2NP_001127931.1  prickle-like protein 2 isoform b

      See identical proteins and their annotated locations for NP_001127931.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2, 3 and 4 encode the same isoform (b), which has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AC122429, AC164636
      Consensus CDS
      CCDS51854.1
      UniProtKB/Swiss-Prot
      A6H652, Q80Y24
      Related
      ENSMUSP00000109073.2, ENSMUST00000113446.8
      Conserved Domains (4) summary
      cd09415
      Location:130188
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:193248
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:253311
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:26122
      PET_Prickle; The PET domain of Prickle
    3. NM_001134460.3NP_001127932.1  prickle-like protein 2 isoform b

      See identical proteins and their annotated locations for NP_001127932.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2, 3 and 4 encode the same isoform (b), which has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AC122429, AC164636
      Consensus CDS
      CCDS51854.1
      UniProtKB/Swiss-Prot
      A6H652, Q80Y24
      Related
      ENSMUSP00000109072.2, ENSMUST00000113445.2
      Conserved Domains (4) summary
      cd09415
      Location:130188
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:193248
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:253311
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:26122
      PET_Prickle; The PET domain of Prickle
    4. NM_001134461.2NP_001127933.1  prickle-like protein 2 isoform b

      See identical proteins and their annotated locations for NP_001127933.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2, 3 and 4 encode the same isoform (b), which has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AC122429, AC164636
      Consensus CDS
      CCDS51854.1
      UniProtKB/Swiss-Prot
      A6H652, Q80Y24
      Related
      ENSMUSP00000109074.2, ENSMUST00000113447.8
      Conserved Domains (4) summary
      cd09415
      Location:130188
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:193248
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:253311
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:26122
      PET_Prickle; The PET domain of Prickle
    5. NM_001404086.1NP_001391015.1  prickle-like protein 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC164636, AC166101

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      92347876..92683233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166119.1XP_036022012.1  prickle-like protein 2 isoform X3

      UniProtKB/Swiss-Prot
      A6H652, Q80Y24
      Conserved Domains (4) summary
      cd09415
      Location:130188
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:193248
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:253311
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:26122
      PET_Prickle; The PET domain of Prickle
    2. XM_030255385.2XP_030111245.1  prickle-like protein 2 isoform X2

      Conserved Domains (4) summary
      cd09415
      Location:171229
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:234289
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:294352
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:67163
      PET_Prickle; The PET domain of Prickle