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    Zfp217 zinc finger protein 217 [ Mus musculus (house mouse) ]

    Gene ID: 228913, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp217provided by MGI
    Official Full Name
    zinc finger protein 217provided by MGI
    Primary source
    MGI:MGI:2685408
    See related
    Ensembl:ENSMUSG00000052056 AllianceGenome:MGI:2685408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm562; ZABC1; Znf217; 4933431C08Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular senescence. Predicted to be located in mitochondrion and nuclear speck. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; paraxial mesenchyme; and tail. Orthologous to human ZNF217 (zinc finger protein 217). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 23.1), thymus adult (RPKM 7.0) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp217 in Genome Data Viewer
    Location:
    2 H3; 2 89.91 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (169950563..169993598, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (170108643..170151677, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene teashirt zinc finger family member 2 Neighboring gene STARR-seq mESC enhancer starr_06500 Neighboring gene cDNA sequence AY702102 Neighboring gene STARR-seq mESC enhancer starr_06501 Neighboring gene STARR-seq mESC enhancer starr_06502 Neighboring gene STARR-seq mESC enhancer starr_06503 Neighboring gene RIKEN cDNA A630075F10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6026 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:169978978-169979087 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:169980510-169980753 Neighboring gene STARR-positive B cell enhancer ABC_E9210 Neighboring gene STARR-positive B cell enhancer ABC_E10165 Neighboring gene STARR-positive B cell enhancer ABC_E2658 Neighboring gene STARR-seq mESC enhancer starr_06515 Neighboring gene predicted gene, 34403 Neighboring gene predicted gene, 17619

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Partial Deficiency of Zfp217 Resists High-Fat Diet-Induced Obesity by Increasing Energy Metabolism in Mice. Zeng Q, et al. Int J Mol Sci, 2021 May 20. PMID 34065474, Free PMC Article
    2. Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming. Aguilo F, et al. Cell Stem Cell, 2015 Dec 3. PMID 26526723, Free PMC Article
    3. The Emerging Role of Zfp217 in Adipogenesis. Xiang H, et al. Int J Mol Sci, 2017 Jun 27. PMID 28653987, Free PMC Article
    4. Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation. Song T, et al. Nucleic Acids Res, 2019 Jul 9. PMID 31037292, Free PMC Article
    5. Zinc finger proteins orchestrate active gene silencing during embryonic stem cell differentiation. Kwak S, et al. Nucleic Acids Res, 2018 Jul 27. PMID 29846698, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Partial Deficiency of Zfp217 Resists High-Fat Diet-Induced Obesity by Increasing Energy Metabolism in Mice.
      Title: Partial Deficiency of Zfp217 Resists High-Fat Diet-Induced Obesity by Increasing Energy Metabolism in Mice.
    2. ZFP217 regulates adipogenesis by controlling mitotic clonal expansion in a METTL3-m(6)A dependent manner.
      Title: ZFP217 regulates adipogenesis by controlling mitotic clonal expansion in a METTL3-m(6)A dependent manner.
    3. Zfp217 couples gene transcription to m6A mRNA modification to facilitate adipogenesis.
      Title: Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation.
    4. Zfp217 and Zfp516 facilitate Ctbp2-mediated repression on active embryonic stem cell genes during differentiation.
      Title: Zinc finger proteins orchestrate active gene silencing during embryonic stem cell differentiation.
    5. Three microRNAs (miR-503-5p, miR-135a-5p and miR-19a-3p) which target Zfp217 were found to suppress the process of adipogenesis. This is the first report showing that Zfp217 has the capacity to regulate adipogenesis.
      Title: The Emerging Role of Zfp217 in Adipogenesis.
    6. ZFP217 regulates N6-methyladenosine mRNA deposition in embryonic stem cells thus contributing to tumorigenesis by dysregulating gene expression programs.
      Title: ZNF217/ZFP217 Meets Chromatin and RNA.
    7. ZFP217 has a role in regulating pluripotency and reprogramming and is coordinated by m(6)A mRNA methylation
      Title: Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming.
    8. results show that ZNF217 regulates ErbB3 expression
      Title: ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells.
    9. These results identify a new CtBP interaction motif and establish ZNF217 as a transcriptional repressor protein that functions, at least in part, by associating with CtBP.
      Title: Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 217

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033299.4 → NP_001028471.1  zinc finger protein 217

      See identical proteins and their annotated locations for NP_001028471.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AL844576
      Consensus CDS
      CCDS17120.1
      UniProtKB/TrEMBL
      Q3U0X6
      Related
      ENSMUSP00000067334.7, ENSMUST00000063710.13
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. NM_001159683.1 → NP_001153155.1  zinc finger protein 217

      See identical proteins and their annotated locations for NP_001153155.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK139547, AL844576, BC116330
      Consensus CDS
      CCDS17120.1
      UniProtKB/TrEMBL
      Q3U0X6
      Related
      ENSMUSP00000104783.2, ENSMUST00000109155.8
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    3. NM_001434160.1 → NP_001421089.1  zinc finger protein 217

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AL844576

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      169950563..169993598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499428.4 → XP_006499491.1  zinc finger protein 217 isoform X1

      See identical proteins and their annotated locations for XP_006499491.1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. XM_006499430.3 → XP_006499493.1  zinc finger protein 217 isoform X1

      See identical proteins and their annotated locations for XP_006499493.1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    3. XM_006499434.4 → XP_006499497.1  zinc finger protein 217 isoform X2

      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    4. XM_006499427.4 → XP_006499490.1  zinc finger protein 217 isoform X1

      See identical proteins and their annotated locations for XP_006499490.1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    5. XM_006499429.5 → XP_006499492.1  zinc finger protein 217 isoform X1

      See identical proteins and their annotated locations for XP_006499492.1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    6. XM_030250755.1 → XP_030106615.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    7. XM_036161709.1 → XP_036017602.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    8. XM_006499431.4 → XP_006499494.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    9. XM_006499432.5 → XP_006499495.1  zinc finger protein 217 isoform X1

      See identical proteins and their annotated locations for XP_006499495.1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    10. XM_006499433.4 → XP_006499496.1  zinc finger protein 217 isoform X1

      See identical proteins and their annotated locations for XP_006499496.1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

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