Ooep oocyte expressed protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ooepprovided by MGI
Official Full Name: oocyte expressed proteinprovided by MGI
Primary source: MGI:MGI:1915218
See related: Ensembl:ENSMUSG00000032346 AllianceGenome:MGI:1915218
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sddr; Floped; Moep19; 2410146L05Rik
Summary: Enables RNA binding activity. Involved in several processes, including cytoskeleton organization; positive regulation of double-strand break repair via homologous recombination; and positive regulation of meiotic nuclear division. Acts upstream of or within several processes, including embryo implantation; establishment or maintenance of apical/basal cell polarity; and protein phosphorylation. Located in apical part of cell; cell cortex; and nucleus. Part of subcortical maternal complex. Is expressed in several structures, including early conceptus; nervous system; nose; ovary; and skeleton. Orthologous to human OOEP (oocyte expressed protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 8.3), ovary adult (RPKM 5.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E1; 9 43.65 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (78284185..78285870, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (78376903..78378588, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mouse embryonic stem cells utilize a unique Filia-Floped protein complex-dependent mechanism to efficiently promote the restart of stalled replication forks, therefore maintaining genomic stability.
Title: Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex.
role in homologous recombination-mediated DNA double-strand break repair in oocytes
Title: Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes.
FLOPED is part of the subcortical maternal complex (SCMC). SCMC is required for formation of the cytoplasmic F-actin meshwork that controls the central position of the spindle and ensures symmetric division.
Title: The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics.
Floped-/- blastocysts had significantly decreased derivation rates.
Title: Maternal-effect Floped gene is essential for the derivation of embryonic stem cells in mice.
The CES5/OOEP is an essential component of the oocyte cytoplasmic lattices and is required for embryonic development at the maternal-zygotic stage transition.
Title: Maternal-effect gene Ces5/Ooep/Moep19/Floped is essential for oocyte cytoplasmic lattice formation and embryonic development at the maternal-zygotic stage transition.
MOEP19 domain directs RNAs essential for normal embryonic development to specific locations in the oocyte and early embryo.
Title: Distribution of RNA binding protein MOEP19 in the oocyte cortex and early embryo indicates pre-patterning related to blastomere polarity and trophectoderm specification.
Results describe a subcortical maternal complex, containing Mater, Floped, TLE6, and Filia, that is essential for preimplantation mouse embryogenesis.
Title: A subcortical maternal complex essential for preimplantation mouse embryogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ooep (e-PCR), detects polymorphism
- UniSTS:546908

Ooep (e-PCR), detects polymorphism
- UniSTS:526831

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic pattern specification	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of apical/basal cell polarity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment or maintenance of apical/basal cell polarity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in replication fork processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of subcortical maternal complex	IDA Inferred from Direct Assay more info	PubMed
part_of subcortical maternal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: oocyte-expressed protein homolog

Names: STAT3 downstream gene and differentiation regulator; factor located in oocytes permitting embryonic development; oocyte and embryo specific protein; oocyte expressed protein homolog (dog); oocyte- and embryo-specific protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.