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    Crh corticotropin releasing hormone [ Mus musculus (house mouse) ]

    Gene ID: 12918, updated on 27-Nov-2024

    Summary

    Official Symbol
    Crhprovided by MGI
    Official Full Name
    corticotropin releasing hormoneprovided by MGI
    Primary source
    MGI:MGI:88496
    See related
    Ensembl:ENSMUSG00000049796 AllianceGenome:MGI:88496
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CRF; Gm1347
    Summary
    This gene encodes a member of the corticotropin-releasing factor family and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is a neuropeptide hormone that binds to the corticotropin releasing hormone receptors (CRHR1 and CRHR2) to stimulate the release of adrenocorticotropic hormone from the pituitary gland in response to stress. The encoded protein may also regulate angiogenesis and inflammation. Homozygous knockout mice for this gene exhibit reduced corticosterone levels while the offspring of these mice die perinatally. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in frontal lobe adult (RPKM 3.0), cortex adult (RPKM 1.9) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Crh in Genome Data Viewer
    Location:
    3 A2; 3 5.75 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (19747565..19749560, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (19693401..19695396, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA alanine 14 (anticodon AGC) Neighboring gene STARR-seq mESC enhancer starr_07098 Neighboring gene tripartite motif-containing 55 Neighboring gene predicted gene, 42189 Neighboring gene STARR-seq mESC enhancer starr_07100 Neighboring gene STARR-seq mESC enhancer starr_07101 Neighboring gene predicted gene, 18864 Neighboring gene STARR-seq mESC enhancer starr_07102 Neighboring gene predicted gene 7442

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC151298

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables corticotropin-releasing hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables corticotropin-releasing hormone receptor 1 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables corticotropin-releasing hormone receptor 1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables corticotropin-releasing hormone receptor 2 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables corticotropin-releasing hormone receptor 2 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adrenal gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in associative learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in associative learning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in diterpenoid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucocorticoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hormone-mediated apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hormone-mediated apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hypothalamus development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within locomotory exploration behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epinephrine secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of epinephrine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glucagon secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of glucagon secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of glucagon secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of luteinizing hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of luteinizing hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of norepinephrine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of corticosterone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of corticosterone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of corticotropin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of corticotropin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cortisol secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cortisol secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cortisol secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of digestive system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of digestive system process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of NMDA receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of serotonin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of serotonin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to aldosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to corticosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ether IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to immobilization stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic transmission, dopaminergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic transmission, dopaminergic ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal dense core vesicle lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in varicosity IEA
    Inferred from Electronic Annotation
    more info
     
    located_in varicosity ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    corticoliberin
    Names
    corticotropin releasing factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205769.3NP_991338.1  corticoliberin preproprotein

      See identical proteins and their annotated locations for NP_991338.1

      Status: REVIEWED

      Source sequence(s)
      BC116921, BE993430, CJ050024
      Consensus CDS
      CCDS17258.1
      UniProtKB/Swiss-Prot
      Q14AA2, Q8CIT0
      Related
      ENSMUSP00000061185.5, ENSMUST00000061294.5
      Conserved Domains (1) summary
      pfam00473
      Location:148185
      CRF; Corticotropin-releasing factor family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      19747565..19749560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)