Nlrp9b NLR family, pyrin domain containing 9B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nlrp9bprovided by MGI
Official Full Name: NLR family, pyrin domain containing 9Bprovided by MGI
Primary source: MGI:MGI:2675377
See related: Ensembl:ENSMUSG00000060508 AllianceGenome:MGI:2675377
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nlrp9; Nalp9b; Nalp-delta
Summary: Predicted to enable ATP binding activity. Involved in defense response to symbiont; positive regulation of interleukin-18 production; and pyroptotic inflammatory response. Acts upstream of or within blastocyst development. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Is expressed in early conceptus; intestine; ovary; and testis. Orthologous to human NLRP9 (NLR family pyrin domain containing 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 5.3), small intestine adult (RPKM 1.7) and 4 other tissues See more
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Genomic context

Location:: 7 A3; 7 9.96 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (19725318..19796867)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19991393..20062942)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maternally contributed Nlrp9b expressed in human and mouse ovarian follicles contributes to early murine preimplantation development.
Title: Maternally contributed Nlrp9b expressed in human and mouse ovarian follicles contributes to early murine preimplantation development.
The findings indicated that NLRP9b(-/-) improved the survival rate of cecal ligation and puncture -induced acute lung injury mice, and inhibited pulmonary histopathological alterations, inflammation, and apoptosis.
Title: Inhibition of NLRP9b attenuates acute lung injury through suppressing inflammation, apoptosis and oxidative stress in murine and cell models.
uncovering and mechanistic characterization of the NLR Nlrp9b that is specifically expressed in intestinal epithelial cells and restricts rotavirus infection
Title: Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.
provide the first evidence that the NLRP9B protein is dispensable for oocyte maturation and early embryonic development in the mouse
Title: NLRP9B protein is dispensable for oocyte maturation and early embryonic development in the mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-18 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyroptotic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of canonical inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of canonical inflammasome complex	ISO Inferred from Sequence Orthology more info
part_of canonical inflammasome complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 9B

Names: NACHT, LRR and PYD containing protein 9b; NLR family, pyrin domain containing 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194058.2 → NP_918947.2 NACHT, LRR and PYD domains-containing protein 9B

See identical proteins and their annotated locations for NP_918947.2

Status: VALIDATED

Source sequence(s)

AY596196

Consensus CDS

CCDS20920.1

UniProtKB/Swiss-Prot

Q66X22, Q6UTW9

UniProtKB/TrEMBL

B9EIZ9

Related

ENSMUSP00000072895.7, ENSMUST00000073151.13

Conserved Domains (6) summary

cd08320
Location:9 → 86

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:694 → 722

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:144 → 308

NACHT; NACHT domain

pfam17776
Location:440 → 555

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:387 → 438

NOD2_WH; NOD2 winged helix domain

cl39015
Location:752 → 955

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

19725318..19796867

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539938.2 → XP_006540001.1 NACHT, LRR and PYD domains-containing protein 9B isoform X1

See identical proteins and their annotated locations for XP_006540001.1

UniProtKB/Swiss-Prot

Q66X22, Q6UTW9

UniProtKB/TrEMBL

B9EIZ9

Conserved Domains (6) summary

cd08320
Location:9 → 86

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:694 → 722

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:144 → 308

NACHT; NACHT domain

pfam17776
Location:440 → 555

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:387 → 438

NOD2_WH; NOD2 winged helix domain

cl39015
Location:752 → 955

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_006539939.2 → XP_006540002.1 NACHT, LRR and PYD domains-containing protein 9B isoform X1

See identical proteins and their annotated locations for XP_006540002.1

UniProtKB/Swiss-Prot

Q66X22, Q6UTW9

UniProtKB/TrEMBL

B9EIZ9

Conserved Domains (6) summary

cd08320
Location:9 → 86

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:694 → 722

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:144 → 308

NACHT; NACHT domain

pfam17776
Location:440 → 555

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:387 → 438

NOD2_WH; NOD2 winged helix domain

cl39015
Location:752 → 955

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_011250564.1 → XP_011248866.1 NACHT, LRR and PYD domains-containing protein 9B isoform X3

UniProtKB/TrEMBL

B9EIZ9

Conserved Domains (6) summary

cd08320
Location:9 → 86

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00034
Location:633 → 667

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:144 → 308

NACHT; NACHT domain

pfam17776
Location:440 → 555

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:387 → 438

NOD2_WH; NOD2 winged helix domain

cl39015
Location:692 → 899

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_011250563.1 → XP_011248865.1 NACHT, LRR and PYD domains-containing protein 9B isoform X2

UniProtKB/TrEMBL

B9EIZ9

Conserved Domains (6) summary

cd08320
Location:9 → 86

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:639 → 667

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:144 → 308

NACHT; NACHT domain

pfam17776
Location:440 → 555

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:387 → 438

NOD2_WH; NOD2 winged helix domain

cl39015
Location:697 → 900

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_011250565.1 → XP_011248867.1 NACHT, LRR and PYD domains-containing protein 9B isoform X4

UniProtKB/TrEMBL

B9EIZ9

Conserved Domains (6) summary

cd08320
Location:9 → 86

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00034
Location:633 → 667

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:144 → 308

NACHT; NACHT domain

pfam17776
Location:440 → 555

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:387 → 438

NOD2_WH; NOD2 winged helix domain

cl39015
Location:692 → 839

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...