Arhgap31 Rho GTPase activating protein 31 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap31provided by MGI
Official Full Name: Rho GTPase activating protein 31provided by MGI
Primary source: MGI:MGI:1333857
See related: Ensembl:ENSMUSG00000022799 AllianceGenome:MGI:1333857
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cdgap; 5830477L08Rik; D330026I07Rik
Summary: Enables GTPase activator activity and SH3 domain binding activity. Acts upstream of or within small GTPase-mediated signal transduction. Located in lamellipodium. Is expressed in several structures, including 1st branchial arch; brain vascular element; heart; retina layer; and surface ectoderm. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and coronary artery disease. Orthologous to human ARHGAP31 (Rho GTPase activating protein 31). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 18.2), ovary adult (RPKM 10.6) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 26.87 cM; 16 B4

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (38418705..38533397, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (38598343..38713035, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CdGAP maintains podocyte function and modulates focal adhesions in a Src kinase-dependent manner.
Title: CdGAP maintains podocyte function and modulates focal adhesions in a Src kinase-dependent manner.
findings are the first to demonstrate the importance of CdGAP in embryonic vascular development and VEGF-induced signaling, and highlight CdGAP as a potential therapeutic target to treat pathological angiogenesis and vascular dysfunction
Title: CdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for vascular development and VEGF-mediated angiogenesis.
Increased levels of endogenous CdGAP in mammary tumor explant cells resulted in increased cell motility and invasion in response to TGF-beta, and downregulation by siRNA inhibited cell motility and invasion. CdGAP is required for TGF-beta effects.
Title: CdGAP is required for transforming growth factor β- and Neu/ErbB-2-induced breast cancer cell motility and invasion.
Data show that intersectin-SH3D interacts directly with a small region of CdGAP highly enriched in basic residues and comprising a novel conserved xKx(K/R)K motif.
Title: Cdc42 GTPase-activating protein (CdGAP) interacts with the SH3D domain of Intersectin through a novel basic-rich motif.
Nudel facilitates cell migration by sequestering Cdc42GAP at the leading edge to stabilize active Cdc42 in response to extracellular stimuli.
Title: Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells.
CdGAP is a novel substrate of extracellular signal-regulated kinase (ERK)1/2 and mediates cross talk between the Ras/mitogen-activated protein kinase pathway and regulation of Rac1 activity.
Title: Extracellular signal-regulated kinase 1 interacts with and phosphorylates CdGAP at an important regulatory site.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U23910 (e-PCR)
- UniSTS:17664

RH132829 (e-PCR)
- UniSTS:216112

AU045686 (e-PCR)
- UniSTS:160571

Arhgap31 (e-PCR), detects polymorphism
- UniSTS:546469

D16Mit90 (e-PCR), detects polymorphism
- UniSTS:127927

D16Ium68 (e-PCR), detects polymorphism
- UniSTS:142067

AU041750 (e-PCR)
- UniSTS:164606

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables SH3 domain binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rho GTPase-activating protein 31

Names: CDC42 GTPase-activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020260.2 → NP_064656.2 rho GTPase-activating protein 31

See identical proteins and their annotated locations for NP_064656.2

Status: VALIDATED

Source sequence(s)

AF151363, AK129309, BB865916

Consensus CDS

CCDS28172.1

UniProtKB/Swiss-Prot

A6X8Z5, Q3TL91, Q3U1T7, Q3UDE7, Q3UUH4, Q6ZPW0, Q9WV94

UniProtKB/TrEMBL

B2RSI0

Related

ENSMUSP00000023487.5, ENSMUST00000023487.5

Conserved Domains (1) summary

cd04384
Location:17 → 211

RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...