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    Mxra7 matrix-remodelling associated 7 [ Mus musculus (house mouse) ]

    Gene ID: 67622, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mxra7provided by MGI
    Official Full Name
    matrix-remodelling associated 7provided by MGI
    Primary source
    MGI:MGI:1914872
    See related
    Ensembl:ENSMUSG00000020814 AllianceGenome:MGI:1914872
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810057P16Rik; E130302J09Rik
    Summary
    Predicted to be located in endoplasmic reticulum. Is expressed in early embryo; ganglia; medulla oblongata basal plate mantle layer; retina; and trigeminal nerve. Orthologous to human MXRA7 (matrix remodeling associated 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 24.9), ovary adult (RPKM 13.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mxra7 in Genome Data Viewer
    Location:
    11 E2; 11 81.49 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116694226..116718953, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116803400..116828127, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC018473 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116644149-116644366 Neighboring gene STARR-seq mESC enhancer starr_31225 Neighboring gene STARR-positive B cell enhancer ABC_E7102 Neighboring gene jumonji domain containing 6 Neighboring gene methyltransferase like 23 Neighboring gene STARR-positive B cell enhancer ABC_E4018 Neighboring gene STARR-positive B cell enhancer ABC_E2376 Neighboring gene serine and arginine-rich splicing factor 2 Neighboring gene major facilitator superfamily domain containing 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Matrix remodeling associated 7 proteins promote cutaneous wound healing through vimentin in coordinating fibroblast functions. Shen Y, et al. Inflamm Regen, 2023 Jan 16. PMID 36647132, Free PMC Article
    2. [The Effect of Matrix Remodeling Associated 7 (MXRA7) Expression on the Biological Function of SHI-1 Cells]. Zheng YD, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2022 Jun. PMID 35680791
    3. Matrix remodeling associated 7 promotes differentiation of bone marrow mesenchymal stem cells toward osteoblasts. Zhou Z, et al. J Cell Physiol, 2019 Aug. PMID 30843215
    4. Matrix Remodeling Associated 7 Deficiency Alleviates Carbon Tetrachloride-Induced Acute Liver Injury in Mice. Lin D, et al. Front Immunol, 2018. PMID 29720975, Free PMC Article
    5. Public data mining plus domestic experimental study defined involvement of the old-yet-uncharacterized gene matrix-remodeling associated 7 (MXRA7) in physiopathology of the eye. Jia C, et al. Gene, 2017 Oct 20. PMID 28847716

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [The Effect of Matrix Remodeling Associated 7 (MXRA7) Expression on the Biological Function of SHI-1 Cells].
      Title: [The Effect of Matrix Remodeling Associated 7 (MXRA7) Expression on the Biological Function of SHI-1 Cells].
    2. MXRA7 influences bone formation by regulating the balance between osteogenesis and adipogenesis in bone marrow mesenchymal stem cells.
      Title: Matrix remodeling associated 7 promotes differentiation of bone marrow mesenchymal stem cells toward osteoblasts.
    3. These data demonstrated that MXRA7 gene might function as a negative modulator in psoriasis development when propsoriatic factors attack, presumably via expression alteration or redistribution of MXRA7 proteins in keratinocytes.
      Title: Altered expression of matrix remodelling associated 7 (MXRA7) in psoriatic epidermis: Evidence for a protective role in the psoriasis imiquimod mouse model.
    4. MXRA7 gene might function as a negative modulator in psoriasis development when propsoriatic factors attack, presumably via expression alteration or redistribution of MXRA7 proteins in keratinocytes.
      Title: Altered expression of matrix remodelling associated 7 (MXRA7) in psoriatic epidermis: Evidence for a protective role in the psoriasis imiquimod mouse model.
    5. MXRA7 influences bone formation via regulating the balance between osteogenesis and adipogenesis in bone marrow mesenchymal stem cells. Deficiency of MXRA7 in mice leads to shorter tibia.
      Title: Matrix remodeling associated 7 promotes differentiation of bone marrow mesenchymal stem cells toward osteoblasts.
    6. We concluded that MXRA7 was an active player in CCl4-induced liver injury
      Title: Matrix Remodeling Associated 7 Deficiency Alleviates Carbon Tetrachloride-Induced Acute Liver Injury in Mice.
    7. MXRA7 is under-expressed during corneal infection and neovascularization.
      Title: Public data mining plus domestic experimental study defined involvement of the old-yet-uncharacterized gene matrix-remodeling associated 7 (MXRA7) in physiopathology of the eye.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    matrix-remodeling-associated protein 7
    Names
    transmembrane anchor protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347633.1 → NP_001334562.1  matrix-remodeling-associated protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645542, BC075618, BE982207
      Consensus CDS
      CCDS83937.1
      UniProtKB/TrEMBL
      Q9D1T2
      Related
      ENSMUSP00000038213.6, ENSMUST00000047715.12

    2. NM_026280.3 → NP_080556.1  matrix-remodeling-associated protein 7 isoform 1

      See identical proteins and their annotated locations for NP_080556.1

      Status: VALIDATED

      Source sequence(s)
      AK075801, CX734756
      Consensus CDS
      CCDS25677.1
      UniProtKB/Swiss-Prot
      A2AA24, B2RVR9, Q8C6F8, Q9CZH7
      Related
      ENSMUSP00000021170.3, ENSMUST00000021170.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116694226..116718953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534006.4 → XP_006534069.1  matrix-remodeling-associated protein 7 isoform X2

    2. XM_036156914.1 → XP_036012807.1  matrix-remodeling-associated protein 7 isoform X1

      UniProtKB/TrEMBL
      Q9D1T2

    RNA

    1. XR_001780042.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZH7.2 GenPept UniProtKB/Swiss-Prot:Q9CZH7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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