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    Rhobtb2 Rho-related BTB domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 246710, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rhobtb2provided by MGI
    Official Full Name
    Rho-related BTB domain containing 2provided by MGI
    Primary source
    MGI:MGI:2180557
    See related
    Ensembl:ENSMUSG00000022075 AllianceGenome:MGI:2180557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dbc2; mKIAA0717; E130206H14Rik
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Predicted to be active in plasma membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; integumental system; and nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 64. Orthologous to human RHOBTB2 (Rho related BTB domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 14.0), frontal lobe adult (RPKM 11.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rhobtb2 in Genome Data Viewer
    Location:
    14 D2; 14 36.1 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70022439..70062296, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (69784990..69824847, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930480K23 gene Neighboring gene STARR-seq mESC enhancer starr_37064 Neighboring gene tumor necrosis factor receptor superfamily, member 10b Neighboring gene PR domain containing 4 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10832 Neighboring gene STARR-positive B cell enhancer ABC_E7329 Neighboring gene STARR-positive B cell enhancer ABC_E5452 Neighboring gene STARR-seq mESC enhancer starr_37068 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70261408-70261517 Neighboring gene STARR-positive B cell enhancer ABC_E9049 Neighboring gene phosphatidylethanolamine binding protein 4 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene ribosomal protein S11 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DBC2, a candidate for a tumor suppressor gene involved in breast cancer. Hamaguchi M, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370419, Free PMC Article
    2. High expression during neurogenesis but not mammogenesis of a murine homologue of the Deleted in Breast Cancer2/Rhobtb2 tumor suppressor. St-Pierre B, et al. Gene Expr Patterns, 2004 Dec. PMID 15567721
    3. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. Ramos S, et al. Gene, 2002 Oct 2. PMID 12426103
    4. Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain. Lutz J, et al. Histochem Cell Biol, 2014 Nov. PMID 24923387
    5. MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein. Schenková K, et al. J Mol Biol, 2012 Oct 5. PMID 22709582

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. There is no connection between elevated expression of mDbc2/Rhobtb2 and a specific stage of mammary gland development, but this gene plays a critical role in the development of the nervous system.
      Title: High expression during neurogenesis but not mammogenesis of a murine homologue of the Deleted in Breast Cancer2/Rhobtb2 tumor suppressor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28699

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho-related BTB domain-containing protein 2
    Names
    deleted in breast cancer 2 gene protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153514.5 → NP_705734.4  rho-related BTB domain-containing protein 2

      See identical proteins and their annotated locations for NP_705734.4

      Status: VALIDATED

      Source sequence(s)
      AC162936
      Consensus CDS
      CCDS27244.1
      UniProtKB/Swiss-Prot
      Q8BYU3, Q8K1A8, Q91V93
      UniProtKB/TrEMBL
      Q8BV20
      Related
      ENSMUSP00000022665.3, ENSMUST00000022665.4
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18359
      Location:480 → 603
      BTB2_POZ_RHOBTB2; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
      cd18531
      Location:608 → 704
      BACK_RHOBTB2; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
      cl38908
      Location:250 → 475
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      70022439..70062296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158600.1 → XP_036014493.1  rho-related BTB domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      Q8BV20
      Conserved Domains (4) summary
      cd01873
      Location:35 → 229
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18359
      Location:502 → 625
      BTB2_POZ_RHOBTB2; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
      cd18531
      Location:630 → 726
      BACK_RHOBTB2; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
      cl38908
      Location:272 → 497
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    2. XM_030247818.2 → XP_030103678.1  rho-related BTB domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8BYU3, Q8K1A8, Q91V93
      UniProtKB/TrEMBL
      Q8BV20
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18359
      Location:480 → 603
      BTB2_POZ_RHOBTB2; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
      cd18531
      Location:608 → 704
      BACK_RHOBTB2; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
      cl38908
      Location:250 → 475
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91V93.2 GenPept UniProtKB/Swiss-Prot:Q91V93

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