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    Eps8l3 EPS8-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 99662, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Eps8l3provided by MGI
    Official Full Name
    EPS8-like 3provided by MGI
    Primary source
    MGI:MGI:2139743
    See related
    Ensembl:ENSMUSG00000040600 AllianceGenome:MGI:2139743
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eps8r3
    Summary
    Predicted to enable actin binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in ruffle membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypotrichosis 5. Orthologous to human EPS8L3 (EPS8 signaling adaptor L3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 84.5), small intestine adult (RPKM 83.8) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eps8l3 in Genome Data Viewer
    Location:
    3 F2.3; 3 46.83 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107781177..107800216)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107873860..107892900)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568636 Neighboring gene STARR-seq mESC enhancer starr_08675 Neighboring gene STARR-positive B cell enhancer ABC_E11209 Neighboring gene 60S ribosomal protein L13-like Neighboring gene RIKEN cDNA 4933431E20 gene Neighboring gene glutathione S-transferase, mu 5 Neighboring gene predicted gene 9515

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Eps8 controls actin-based motility by capping the barbed ends of actin filaments. Disanza A, et al. Nat Cell Biol, 2004 Dec. PMID 15558031
    2. In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure. Tocchetti A, et al. Genomics, 2003 Feb. PMID 12620401
    3. The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Offenhäuser N, et al. Mol Biol Cell, 2004 Jan. PMID 14565974, Free PMC Article
    4. Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Bell SM, et al. Dev Biol, 2013 Mar 15. PMID 23266329, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ruffle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of hair cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of hair cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    epidermal growth factor receptor kinase substrate 8-like protein 3
    Names
    EPS8-like protein 3
    EPS8-related protein 3
    ESP8-like 3
    epidermal growth factor receptor pathway substrate 8 related protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133867.2 → NP_598628.1  epidermal growth factor receptor kinase substrate 8-like protein 3

      See identical proteins and their annotated locations for NP_598628.1

      Status: VALIDATED

      Source sequence(s)
      AC079042, AY074932
      Consensus CDS
      CCDS38594.1
      UniProtKB/Swiss-Prot
      Q3TJ14, Q91WL0
      Related
      ENSMUSP00000042004.9, ENSMUST00000037375.10
      Conserved Domains (3) summary
      cd11764
      Location:462 → 514
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:25 → 146
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
      cl15755
      Location:531 → 596
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      107781177..107800216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502463.5 → XP_006502526.2  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006502526.2

      Conserved Domains (3) summary
      cd11764
      Location:462 → 514
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:25 → 146
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
      cl15755
      Location:531 → 596
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_006502465.5 → XP_006502528.2  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006502528.2

      Conserved Domains (3) summary
      cd11764
      Location:462 → 514
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:25 → 146
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
      cl15755
      Location:531 → 596
      SAM_superfamily; SAM (Sterile alpha motif )

    3. XM_006502464.4 → XP_006502527.2  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006502527.2

      UniProtKB/Swiss-Prot
      Q3TJ14, Q91WL0
      Conserved Domains (3) summary
      cd11764
      Location:462 → 514
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:25 → 146
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
      cl15755
      Location:531 → 596
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WL0.1 GenPept UniProtKB/Swiss-Prot:Q91WL0

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