Layn layilin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Laynprovided by MGI
Official Full Name: layilinprovided by MGI
Primary source: MGI:MGI:2685357
See related: Ensembl:ENSMUSG00000060594 AllianceGenome:MGI:2685357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm511; E030012M19Rik
Summary: Predicted to enable hyaluronic acid binding activity. Predicted to be located in cell surface and ruffle. Is expressed in brain and trigeminal ganglion. Orthologous to human LAYN (layilin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 1.6), ovary adult (RPKM 1.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 27.79 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (50966323..50988501, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (51055023..51077209, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Layilin Anchors Regulatory T Cells in Skin.
Title: Layilin Anchors Regulatory T Cells in Skin.
Layilin augments integrin activation to promote antitumor immunity.
Title: Layilin augments integrin activation to promote antitumor immunity.
LAYN is involved in the TNF-alpha-induced epithelial-mesenchymal transformation (EMT) of renal tubular epithelial cells.
Title: Roles of layilin in TNF-α-induced epithelial-mesenchymal transformation of renal tubular epithelial cells.
The structure of the talin/layilin complex, which shows that talin binds integrins, PIPK1gamma and layilin in similar although subtly different ways, is reported.
Title: Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info
enables hyaluronic acid binding	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: layilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033534.1 → NP_001028706.1 layilin precursor

See identical proteins and their annotated locations for NP_001028706.1

Status: VALIDATED

Source sequence(s)

AC119831

Consensus CDS

CCDS52791.1

UniProtKB/Swiss-Prot

E9QQ23, Q3TMU7, Q8C351

UniProtKB/TrEMBL

A4QPF5

Related

ENSMUSP00000096379.4, ENSMUST00000098782.4

Conserved Domains (1) summary

cd03595
Location:38 → 186

CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

50966323..50988501 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510330.5 → XP_006510393.1 layilin isoform X2

Conserved Domains (1) summary

cd03595
Location:38 → 186

CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin
XM_006510329.4 → XP_006510392.1 layilin isoform X1

UniProtKB/TrEMBL

A4QPF5

Conserved Domains (2) summary

cd03595
Location:30 → 178

CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin

pfam15102
Location:185 → 317

TMEM154; TMEM154 protein family