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    Marchf4 membrane associated ring-CH-type finger 4 [ Mus musculus (house mouse) ]

    Gene ID: 381270, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Marchf4provided by MGI
    Official Full Name
    membrane associated ring-CH-type finger 4provided by MGI
    Primary source
    MGI:MGI:2683550
    See related
    Ensembl:ENSMUSG00000039372 AllianceGenome:MGI:2683550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    March4; MARCH-IV; mKIAA1399
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in Golgi membrane. Predicted to be active in Golgi stack and trans-Golgi network. Orthologous to human MARCHF4 (membrane associated ring-CH-type finger 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 4.1), whole brain E14.5 (RPKM 3.0) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Marchf4 in Genome Data Viewer
    Location:
    1 C3; 1 36.54 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (72466271..72576454, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (72427112..72537159, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4322 Neighboring gene STARR-seq mESC enhancer starr_01273 Neighboring gene STARR-seq mESC enhancer starr_01274 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 5 Neighboring gene STARR-seq mESC enhancer starr_01276 Neighboring gene predicted gene, 39661 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01277 Neighboring gene SNF2 related chromatin remodeling ATPase like 1 Neighboring gene STARR-positive B cell enhancer ABC_E1548 Neighboring gene STARR-seq mESC enhancer starr_01281 Neighboring gene predicted gene, 39662 Neighboring gene STARR-seq mESC enhancer starr_01283 Neighboring gene ankyrin and armadillo repeat containing Neighboring gene ribosomal protein L19 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development. Li Q, et al. PLoS Genet, 2014 Jul. PMID 25079229, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1399

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi stack IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi stack ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF4
    Names
    E3 ubiquitin-protein ligase MARCH4
    RING-type E3 ubiquitin transferase MARCH4
    RING-type E3 ubiquitin transferase MARCHF4
    membrane-associated RING finger protein 4
    membrane-associated RING-CH protein IV
    membrane-associated ring finger (C3HC4) 4
    NP_001038998.1
    NP_001408016.1
    XP_036021943.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045533.2 → NP_001038998.1  E3 ubiquitin-protein ligase MARCHF4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001038998.1

      Status: VALIDATED

      Source sequence(s)
      AC114629, AC163484
      Consensus CDS
      CCDS15034.1
      UniProtKB/Swiss-Prot
      Q4QQN4, Q80TE3
      Related
      ENSMUSP00000042803.6, ENSMUST00000047786.6
      Conserved Domains (1) summary
      cd16811
      Location:161 → 211
      RING_CH-C4HC3_MARCH4_9; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH4, MARCH9, and similar proteins

    2. NM_001421087.1 → NP_001408016.1  E3 ubiquitin-protein ligase MARCHF4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC114629, AC163484

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      72466271..72576454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166050.1 → XP_036021943.1  E3 ubiquitin-protein ligase MARCHF4 isoform X1

      Conserved Domains (2) summary
      cd00162
      Location:162 → 207
      RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
      cl17238
      Location:161 → 211
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RNA

    1. XR_004942942.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TE3.3 GenPept UniProtKB/Swiss-Prot:Q80TE3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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