Usp24 ubiquitin specific peptidase 24 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp24provided by MGI
Official Full Name: ubiquitin specific peptidase 24provided by MGI
Primary source: MGI:MGI:1919936
See related: Ensembl:ENSMUSG00000028514 AllianceGenome:MGI:1919936
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B130021E18; 2700066K03Rik; 2810030C21Rik
Summary: Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Is expressed in olfactory cortex. Orthologous to human USP24 (ubiquitin specific peptidase 24). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 8.3), thymus adult (RPKM 7.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 49.44 cM

Exon count:: 71

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (106173179..106303798)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (106315980..106446613)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of NF-kappaB by USP24 aggravates ferroptosis in diabetic cardiomyopathy.
Title: Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy.
USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
Title: USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI414051 (e-PCR)
- UniSTS:159264

RH126753 (e-PCR)
- UniSTS:207649

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 24

Names: deubiquitinating enzyme 24; ubiquitin specific protease 24; ubiquitin thioesterase 24; ubiquitin thiolesterase 24; ubiquitin-specific-processing protease 24

NP_899048.2

EC 3.4.19.12

XP_006503239.1

EC 3.4.19.12

XP_006503240.1

EC 3.4.19.12

XP_006503241.1

EC 3.4.19.12

XP_006503243.1

EC 3.4.19.12

XP_036020087.1

EC 3.4.19.12

XP_036020089.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183225.2 → NP_899048.2 ubiquitin carboxyl-terminal hydrolase 24

See identical proteins and their annotated locations for NP_899048.2

Status: VALIDATED

Source sequence(s)

AL840623, AL954352

Consensus CDS

CCDS51251.1

UniProtKB/Swiss-Prot

B1AY13, Q8BLI7

Conserved Domains (3) summary

cd02659
Location:1684 → 2041

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd14286
Location:6 → 42

UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins

pfam00443
Location:1686 → 2036

UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

106173179..106303798

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503180.5 → XP_006503243.1 ubiquitin carboxyl-terminal hydrolase 24 isoform X6

Conserved Domains (2) summary

cd14286
Location:6 → 42

UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins

cd17065
Location:972 → 1050

Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
XM_036164196.1 → XP_036020089.1 ubiquitin carboxyl-terminal hydrolase 24 isoform X5

Conserved Domains (3) summary

cd14286
Location:6 → 42

UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins

cd17065
Location:972 → 1050

Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins

cl02553
Location:1704 → 1865

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
XM_006503177.5 → XP_006503240.1 ubiquitin carboxyl-terminal hydrolase 24 isoform X2

Conserved Domains (3) summary

cd02659
Location:1704 → 2061

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd14286
Location:6 → 42

UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins

cd17065
Location:972 → 1050

Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
XM_006503176.5 → XP_006503239.1 ubiquitin carboxyl-terminal hydrolase 24 isoform X1

UniProtKB/TrEMBL

A0AAG1F6P4

Related

ENSMUSP00000092538.6, ENSMUST00000094933.6

Conserved Domains (3) summary

cd02659
Location:1704 → 2061

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd14286
Location:6 → 42

UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins

cd17065
Location:972 → 1050

Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
XM_036164194.1 → XP_036020087.1 ubiquitin carboxyl-terminal hydrolase 24 isoform X3

Conserved Domains (2) summary

cd02659
Location:1532 → 1889

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd17065
Location:800 → 878

Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
XM_006503178.4 → XP_006503241.1 ubiquitin carboxyl-terminal hydrolase 24 isoform X4

Conserved Domains (2) summary

cd02659
Location:1092 → 1449

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd17065
Location:360 → 438

Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins