Syt2 synaptotagmin II [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Syt2provided by MGI
Official Full Name: synaptotagmin IIprovided by MGI
Primary source: MGI:MGI:99666
See related: Ensembl:ENSMUSG00000026452 AllianceGenome:MGI:99666
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IP4BP; sytII; mKIAA4194
Summary: This gene encodes a member of the synaptotagmin protein family. Synaptotagmin proteins are involved in membrane trafficking and are characterized by an N-terminal transmembrane region as well as tandem calcium binding domains. The encoded protein is able to bind inositol polyphosphate and is thought to be involved in synaptic function and neurotransmitter release. [provided by RefSeq, Sep 2017]
Expression: Biased expression in cerebellum adult (RPKM 41.6) and cortex adult (RPKM 3.9) See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 58.24 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (134574319..134680887)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (134646534..134753149)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest a physiological role for IPMK in regulating expression of Syt2.
Title: Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain.
Authors propose that the strong reduction of Syt2 and SV2B are key factors of the functional synaptic alteration and that the physiological downregulation of Syt1 plays a determinant role in muscle vulnerability in SMA
Title: Synaptotagmin-2, and -1, linked to neurotransmission impairment and vulnerability in Spinal Muscular Atrophy.
Deletion of Syt2 severely reduced and delayed disynaptic inhibition following parallel fiber stimulation and as release sensor at GABAergic basket cell-Purkinje cell synapses ensures fast and efficient feedforward inhibition in cerebellar microcircuit.
Title: Synaptotagmin 2 Is the Fast Ca(2+) Sensor at a Central Inhibitory Synapse.
aM inhibitors or the inhibition of the Ca(2+)-calmodulin-Munc13-1 signaling pathway only impaired the uptake of Syt2 while leaving membrane retrieval intact, indicating different recycling mechanisms for membranes and vesicle proteins. Our data identify a novel mechanism of stimulus- and Ca(2+)-dependent regulation of coordinated endocytosis of synaptic membranes and vesicle proteins.
Title: Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice.
we identify Syt2 as a functionally important Ca(2+) sensor at fast-releasing inhibitory synapses, and show that Syt1 and Syt2 can redundantly control transmitter release at specific brain synapses
Title: Synaptotagmin2 (Syt2) Drives Fast Release Redundantly with Syt1 at the Output Synapses of Parvalbumin-Expressing Inhibitory Neurons.
demonstrates a developmental Syt1-Syt2 isoform switch at an identified synapse, a mechanism that could fine-tune the speed, reliability, and plasticity of transmitter release at fast releasing CNS synapses.
Title: A Synaptotagmin Isoform Switch during the Development of an Identified CNS Synapse.
the combined inactivation of all 3 E-Syt genes has no effect on mouse viability or fertility.
Title: Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility.
The 2.3-A structure of a ternary complex of botulinum neurotoxin type B bound to both its protein receptor synaptotagmin II and its ganglioside receptor GD1a, is reported.
Title: Structure of dual receptor binding to botulinum neurotoxin B.
Synaptotagmins 1 and 2 as mediators of rapid exocytosis at nerve terminals: the dyad hypothesis
Title: Synaptotagmins 1 and 2 as mediators of rapid exocytosis at nerve terminals: the dyad hypothesis.
Syt2 make it an excellent marker for analyzing the development and plasticity of perisomatic inhibitory innervations onto both excitatory and inhibitory neurons in the visual cortex.
Title: Synaptotagmin-2 is a reliable marker for parvalbumin positive inhibitory boutons in the mouse visual cortex.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Chemically induced (other) (1) 1 citation
Endonuclease-mediated (2)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

25.mHAa9h1.seq (e-PCR)
- UniSTS:123710

MDB0795 (e-PCR)
- UniSTS:125036

RH125086 (e-PCR)
- UniSTS:161908

Syt2 (e-PCR), detects polymorphism
- UniSTS:507261

BB351896 (e-PCR)
- UniSTS:208812

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion sensor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables inositol 1,3,4,5 tetrakisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent activation of synaptic vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-dependent activation of synaptic vesicle fusion	IEP Inferred from Expression Pattern more info	PubMed
involved_in calcium-dependent activation of synaptic vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion-dependent exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in chromaffin granule membrane	IEA Inferred from Electronic Annotation more info
is_active_in dense core granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IEP Inferred from Expression Pattern more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: synaptotagmin-2

Names: IP4-binding protein; inositol polyphosphate-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355726.2 → NP_001342655.1 synaptotagmin-2

Status: REVIEWED

Source sequence(s)

AC131591

Consensus CDS

CCDS15312.1

UniProtKB/Swiss-Prot

P46097, Q8R0E1

UniProtKB/TrEMBL

A0A0R4J2C2

Related

ENSMUSP00000112438.2, ENSMUST00000121990.2

Conserved Domains (3) summary

cd08385
Location:142 → 264

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:274 → 409

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

cd21964
Location:4 → 116

Syt2_N; N-terminal domain of synaptotagmin-2 (Syt2) and similar proteins
NM_001421363.1 → NP_001408292.1 synaptotagmin-2

Status: REVIEWED

Source sequence(s)

AC122771, AC131591

UniProtKB/TrEMBL

A0A0R4J2C2
NM_009307.5 → NP_033333.2 synaptotagmin-2

See identical proteins and their annotated locations for NP_033333.2

Status: REVIEWED

Source sequence(s)

AC122771, AC131591

Consensus CDS

CCDS15312.1

UniProtKB/Swiss-Prot

P46097, Q8R0E1

UniProtKB/TrEMBL

A0A0R4J2C2

Related

ENSMUSP00000140081.2, ENSMUST00000188842.7

Conserved Domains (3) summary

cd08385
Location:142 → 264

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:274 → 409

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

cd21964
Location:4 → 116

Syt2_N; N-terminal domain of synaptotagmin-2 (Syt2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

134574319..134680887

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163153.1 → XP_036019046.1 synaptotagmin-2 isoform X1

UniProtKB/Swiss-Prot

P46097, Q8R0E1

UniProtKB/TrEMBL

A0A0R4J2C2

Conserved Domains (3) summary

cd08385
Location:142 → 264

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:274 → 409

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

cd21964
Location:4 → 116

Syt2_N; N-terminal domain of synaptotagmin-2 (Syt2) and similar proteins
XM_006529324.4 → XP_006529387.1 synaptotagmin-2 isoform X2

Conserved Domains (2) summary

cd08402
Location:101 → 236

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

cl14603
Location:1 → 91

C2; C2 domain