Gpnmb glycoprotein (transmembrane) nmb [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpnmbprovided by MGI
Official Full Name: glycoprotein (transmembrane) nmbprovided by MGI
Primary source: MGI:MGI:1934765
See related: Ensembl:ENSMUSG00000029816 AllianceGenome:MGI:1934765
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ipd; Dchil; DC-HIL
Summary: Enables heparin binding activity and integrin binding activity. Involved in several processes, including negative regulation of tumor necrosis factor production; positive regulation of ERK1 and ERK2 cascade; and positive regulation of protein phosphorylation. Acts upstream of or within cell adhesion. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including brain; eye; heart ventricle; hemolymphoid system; and mesenchyme derived from neural crest. Used to study pigment dispersion syndrome. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 3. Orthologous to human GPNMB (glycoprotein nmb). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 24.4), genital fat pad adult (RPKM 18.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B2.3; 6 23.82 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (49013449..49044413)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (49036518..49058182)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and limits fibrosis by suppressing GPNMB-mediated TGF-beta signaling.
Title: The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and limits fibrosis by suppressing GPNMB-mediated TGF-β signaling.
Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma.
Title: Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma.
Roles of Activin A and Gpnmb in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Title: Roles of Activin A and Gpnmb in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Single-cell transcriptome sequencing-based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis.
Title: Single-cell transcriptome sequencing-based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis.
Role of Gpnmb in atherosclerosis of female mice.
Title: Role of Gpnmb in atherosclerosis of female mice.
Tumor endothelial cell-induced CD8(+) T-cell exhaustion via GPNMB in hepatocellular carcinoma.
Title: Tumor endothelial cell-induced CD8(+) T-cell exhaustion via GPNMB in hepatocellular carcinoma.
Glycoprotein nonmetastatic melanoma protein B regulates lysosomal integrity and lifespan of senescent cells.
Title: Glycoprotein nonmetastatic melanoma protein B regulates lysosomal integrity and lifespan of senescent cells.
GPNMB mitigates Alzheimer's disease and enhances autophagy via suppressing the mTOR signal.
Title: GPNMB mitigates Alzheimer's disease and enhances autophagy via suppressing the mTOR signal.
Genetic ablation of Gpnmb does not alter synuclein-related pathology.
Title: Genetic ablation of Gpnmb does not alter synuclein-related pathology.
Anti-inflammatory role of Gpnmb in adipose tissue of mice.
Title: Anti-inflammatory role of Gpnmb in adipose tissue of mice.

Submit: New GeneRIF Correction See all GeneRIFs (62)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Spontaneous (1) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rab13 (e-PCR), detects polymorphism
- UniSTS:281110

D6Dcr8 (e-PCR), detects polymorphism
- UniSTS:507763

D6Mit142 (e-PCR), detects polymorphism
- UniSTS:130685

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables syndecan binding	IEA Inferred from Electronic Annotation more info
enables syndecan binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell signaling	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	IC Inferred by Curator more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of tissue remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tissue remodeling	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in melanosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transmembrane glycoprotein NMB

Names: dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; dendritic cell-associated transmembrane protein; iris pigment dispersion; osteoactivin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053110.4 → NP_444340.3 transmembrane glycoprotein NMB precursor

See identical proteins and their annotated locations for NP_444340.3

Status: VALIDATED

Source sequence(s)

AC153620, AK171465, AK171517, BY205729

Consensus CDS

CCDS20122.1

UniProtKB/Swiss-Prot

Q3U3R9, Q8BVV9, Q8BXL4, Q99P91, Q9QXA0

UniProtKB/TrEMBL

Q3TAV1, Q3TWC7

Related

ENSMUSP00000031840.8, ENSMUST00000031840.10

Conserved Domains (1) summary

cd00146
Location:256 → 316

PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

49013449..49044413

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152412.1 → XP_036008305.1 transmembrane glycoprotein NMB isoform X1

UniProtKB/TrEMBL

Q8BVA0

Related

ENSMUSP00000145376.2, ENSMUST00000204260.2

Conserved Domains (1) summary

cd00146
Location:256 → 316

PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...