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    Atxn2 ataxin 2 [ Mus musculus (house mouse) ]

    Gene ID: 20239, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atxn2provided by MGI
    Official Full Name
    ataxin 2provided by MGI
    Primary source
    MGI:MGI:1277223
    See related
    Ensembl:ENSMUSG00000042605 AllianceGenome:MGI:1277223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ATX2; Sca2; 9630045M23Rik
    Summary
    Predicted to enable epidermal growth factor receptor binding activity and mRNA binding activity. Acts upstream of or within several processes, including homeostasis of number of cells; neuromuscular process; and neuron differentiation. Located in perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; sensory organ; spleen; and submandibular gland primordium. Used to study spinocerebellar ataxia type 2. Human ortholog(s) of this gene implicated in late onset Parkinson's disease and spinocerebellar ataxia type 2. Orthologous to human ATXN2 (ataxin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 15.1), testis adult (RPKM 13.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atxn2 in Genome Data Viewer
    Location:
    5 F; 5 61.93 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121849794..121954372)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121711609..121814950)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14261 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 12 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 10 Neighboring gene BRCA1 associated protein Neighboring gene STARR-seq mESC enhancer starr_14264 Neighboring gene microRNA 7031 Neighboring gene SH2B adaptor protein 3 Neighboring gene predicted gene, 32422

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Antisense oligonucleotides targeting basal forebrain ATXN2 enhances spatial memory and ameliorates sleep deprivation-induced fear memory impairment in mice. Ma T, et al. Brain Behav, 2023 Jun. PMID 37072935, Free PMC Article
    2. Dissociated fear and spatial learning in mice with deficiency of ataxin-2. Huynh DP, et al. PLoS One, 2009 Jul 20. PMID 19617910, Free PMC Article
    3. Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2. Hansen ST, et al. Hum Mol Genet, 2013 Jan 15. PMID 23087021, Free PMC Article
    4. Ataxin-2 modulates the levels of Grb2 and SRC but not ras signaling. Drost J, et al. J Mol Neurosci, 2013 Sep. PMID 23335000, Free PMC Article
    5. Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate. Fittschen M, et al. Neurogenetics, 2015 Jul. PMID 25721894, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Antisense oligonucleotides targeting basal forebrain ATXN2 enhances spatial memory and ameliorates sleep deprivation-induced fear memory impairment in mice.
      Title: Antisense oligonucleotides targeting basal forebrain ATXN2 enhances spatial memory and ameliorates sleep deprivation-induced fear memory impairment in mice.
    2. Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions.
      Title: Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions.
    3. ALS-associated genes in SCA2 mouse spinal cord transcriptomes.
      Title: ALS-associated genes in SCA2 mouse spinal cord transcriptomes.
    4. Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule-Purkinje Neuron Synaptic Strength.
      Title: Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule-Purkinje Neuron Synaptic Strength.
    5. The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression.
      Title: The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression.
    6. An Atxn2-CAG100-knock-in mouse model of SCA2 was generated with intact ATXN2 expression regulation.
      Title: Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation.
    7. Ataxin-2 knockout mice exhibit progressive obesity, dyslipidemia, and insulin resistance.
      Title: In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism.
    8. Atxn2(-/-) mice showed an unstable rhythmicity of locomotor activity, but the level of PER1 and PER2 IR in the SCN did not differ between genotypes.
      Title: Impact of Ataxin-2 knock out on circadian locomotor behavior and PER immunoreaction in the SCN of mice.
    9. Findings provide evidence that the physiological functions and protein interactions of ATXN2 are relevant for calcium-mediated excitation of Purkinje cells as well as for ATXN2-triggered neurotoxicity.
      Title: Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway.
    10. Results from global proteome and metabolome profiling of Atxn2-KO mouse liver and cerebellum indicates that ATXN2 modulates nutrition and basal metabolism.
      Title: Ataxin-2 (Atxn2)-Knock-Out Mice Show Branched Chain Amino Acids and Fatty Acids Pathway Alterations.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables DNA binding domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in P-body assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebellar Purkinje cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ataxin-2
    Names
    spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2)
    spinocerebellar ataxia 2 homolog
    spinocerebellar ataxia type 2 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359153.2 → NP_001346082.1  ataxin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113302, AC116104
      UniProtKB/TrEMBL
      Q3UX07
      Conserved Domains (5) summary
      pfam06741
      Location:141 → 202
      LsmAD; LsmAD domain
      pfam14438
      Location:1 → 74
      SM-ATX; Ataxin 2 SM domain
      cl26386
      Location:267 → 436
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
      cl26464
      Location:593 → 911
      Atrophin-1; Atrophin-1 family
      cl28087
      Location:524 → 654
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    2. NM_009125.3 → NP_033151.3  ataxin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC113302, AC116104
      Consensus CDS
      CCDS39250.1
      Related
      ENSMUSP00000056715.8, ENSMUST00000051950.14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      121849794..121954372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254244.2 → XP_030110104.1  ataxin-2 isoform X12

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (6) summary
      PHA03247
      Location:680 → 998
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK07003
      Location:354 → 523
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:661 → 676
      PAM2; Ataxin-2 C-terminal region
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    2. XM_030254262.1 → XP_030110122.1  ataxin-2 isoform X31

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (6) summary
      PHA03247
      Location:680 → 998
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK07003
      Location:354 → 523
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:661 → 676
      PAM2; Ataxin-2 C-terminal region
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    3. XM_030254265.2 → XP_030110125.1  ataxin-2 isoform X34

      UniProtKB/TrEMBL
      F6U2C2
      Conserved Domains (6) summary
      PHA03247
      Location:680 → 998
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK07003
      Location:354 → 523
      PRK07003; DNA polymerase III subunit gamma/tau
      PRK10263
      Location:611 → 741
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    4. XM_030254263.2 → XP_030110123.1  ataxin-2 isoform X32

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (6) summary
      PHA03247
      Location:386 → 992
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam03154
      Location:743 → 1116
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam09770
      Location:751 → 923
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    5. XM_030254234.2 → XP_030110094.1  ataxin-2 isoform X1

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (6) summary
      PHA03247
      Location:762 → 1080
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK12323
      Location:399 → 606
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:743 → 758
      PAM2; Ataxin-2 C-terminal region
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    6. XM_030254251.2 → XP_030110111.1  ataxin-2 isoform X18

      UniProtKB/TrEMBL
      F6U2C2
      Conserved Domains (6) summary
      PHA03247
      Location:762 → 1080
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:693 → 823
      PRK10263; DNA translocase FtsK; Provisional
      PRK12323
      Location:399 → 606
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    7. XM_030254235.2 → XP_030110095.1  ataxin-2 isoform X2

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (6) summary
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK12323
      Location:399 → 606
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:743 → 758
      PAM2; Ataxin-2 C-terminal region
      pfam03154
      Location:755 → 1142
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    8. XM_030254240.2 → XP_030110100.1  ataxin-2 isoform X8

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (6) summary
      PHA03247
      Location:701 → 1019
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam07145
      Location:682 → 697
      PAM2; Ataxin-2 C-terminal region
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam11489
      Location:452 → 761
      Aim21; Altered inheritance of mitochondria protein 21
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    9. XM_030254242.2 → XP_030110102.1  ataxin-2 isoform X10

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (5) summary
      PHA03247
      Location:689 → 1007
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam07145
      Location:670 → 685
      PAM2; Ataxin-2 C-terminal region
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    10. XM_030254243.1 → XP_030110103.1  ataxin-2 isoform X11

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (5) summary
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK12323
      Location:399 → 606
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam09770
      Location:740 → 1009
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    11. XM_030254258.2 → XP_030110118.1  ataxin-2 isoform X27

      UniProtKB/TrEMBL
      F6U2C2
      Conserved Domains (5) summary
      PHA03247
      Location:483 → 1062
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam09770
      Location:740 → 1009
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    12. XM_030254241.2 → XP_030110101.1  ataxin-2 isoform X9

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (6) summary
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK12323
      Location:399 → 606
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:743 → 758
      PAM2; Ataxin-2 C-terminal region
      pfam03154
      Location:755 → 1138
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    13. XM_030254252.2 → XP_030110112.1  ataxin-2 isoform X20

      UniProtKB/TrEMBL
      F6U2C2
      Conserved Domains (6) summary
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK12323
      Location:399 → 606
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam03154
      Location:691 → 1067
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam09770
      Location:763 → 935
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    14. XM_030254245.1 → XP_030110105.1  ataxin-2 isoform X13

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (6) summary
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK12323
      Location:399 → 606
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:743 → 758
      PAM2; Ataxin-2 C-terminal region
      pfam03154
      Location:755 → 1120
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    15. XM_030254259.1 → XP_030110119.1  ataxin-2 isoform X28

      UniProtKB/TrEMBL
      F6U2C2
      Conserved Domains (6) summary
      PHA03247
      Location:485 → 940
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:899 → 1066
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam09770
      Location:763 → 951
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    16. XM_017320749.2 → XP_017176238.1  ataxin-2 isoform X19

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (5) summary
      PHA03247
      Location:386 → 928
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam03154
      Location:743 → 1098
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    17. XM_030254261.1 → XP_030110121.1  ataxin-2 isoform X30

      UniProtKB/TrEMBL
      F6U2C2
      Conserved Domains (6) summary
      PHA03247
      Location:473 → 928
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:887 → 1054
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam09770
      Location:751 → 939
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    18. XM_030254236.1 → XP_030110096.1  ataxin-2 isoform X4

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (6) summary
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK12323
      Location:399 → 606
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:743 → 758
      PAM2; Ataxin-2 C-terminal region
      pfam03154
      Location:755 → 1126
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    19. XM_030254237.1 → XP_030110097.1  ataxin-2 isoform X5

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (6) summary
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK12323
      Location:399 → 606
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:743 → 758
      PAM2; Ataxin-2 C-terminal region
      pfam03154
      Location:755 → 1124
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    20. XM_030254239.1 → XP_030110099.1  ataxin-2 isoform X7

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (5) summary
      PHA03247
      Location:386 → 928
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam03154
      Location:743 → 1112
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    21. XM_030254249.1 → XP_030110109.1  ataxin-2 isoform X16

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (5) summary
      PHA03247
      Location:439 → 869
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam03154
      Location:682 → 1053
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    22. XM_017320748.3 → XP_017176237.1  ataxin-2 isoform X3

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (5) summary
      PHA03247
      Location:386 → 992
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam03154
      Location:743 → 1130
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    23. XM_030254246.2 → XP_030110106.1  ataxin-2 isoform X14

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (6) summary
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK07003
      Location:354 → 523
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:661 → 676
      PAM2; Ataxin-2 C-terminal region
      pfam03154
      Location:673 → 1060
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    24. XM_036164934.1 → XP_036020827.1  ataxin-2 isoform X25

      UniProtKB/TrEMBL
      F6U2C2
      Conserved Domains (6) summary
      PHA03247
      Location:750 → 1068
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:681 → 811
      PRK10263; DNA translocase FtsK; Provisional
      PRK12323
      Location:387 → 569
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:88 → 161
      SM-ATX; Ataxin 2 SM domain

    25. XM_030254250.2 → XP_030110110.1  ataxin-2 isoform X17

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (5) summary
      PHA03247
      Location:386 → 1022
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam09770
      Location:728 → 997
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    26. XM_030254260.2 → XP_030110120.1  ataxin-2 isoform X29

      UniProtKB/TrEMBL
      F6U2C2
      Related
      ENSMUSP00000124070.2, ENSMUST00000161064.8
      Conserved Domains (5) summary
      PHA03247
      Location:473 → 930
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam09770
      Location:728 → 997
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    27. XM_017320750.3 → XP_017176239.1  ataxin-2 isoform X26

      UniProtKB/TrEMBL
      F6U2C2
      Conserved Domains (5) summary
      PHA03247
      Location:386 → 992
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam09770
      Location:751 → 923
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    28. XM_030254266.2 → XP_030110126.1  ataxin-2 isoform X35

      UniProtKB/TrEMBL
      F6U2C2
      Conserved Domains (6) summary
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK07003
      Location:354 → 523
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam03154
      Location:609 → 985
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam09770
      Location:681 → 853
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    29. XM_030254238.2 → XP_030110098.1  ataxin-2 isoform X6

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (5) summary
      PHA03247
      Location:386 → 1022
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam09770
      Location:728 → 997
      PAT1; Topoisomerase II-associated protein PAT1
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    30. XM_030254255.2 → XP_030110115.1  ataxin-2 isoform X22

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (6) summary
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK07003
      Location:354 → 523
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:661 → 676
      PAM2; Ataxin-2 C-terminal region
      pfam03154
      Location:673 → 1044
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    31. XM_030254257.2 → XP_030110117.1  ataxin-2 isoform X24

      UniProtKB/TrEMBL
      E9QM77
      Conserved Domains (6) summary
      COG5180
      Location:174 → 318
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK07003
      Location:354 → 523
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:661 → 676
      PAM2; Ataxin-2 C-terminal region
      pfam03154
      Location:673 → 1042
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:228 → 289
      LsmAD; LsmAD domain
      pfam14438
      Location:85 → 161
      SM-ATX; Ataxin 2 SM domain

    32. XM_030254247.2 → XP_030110107.1  ataxin-2 isoform X15

      UniProtKB/TrEMBL
      Q3UX07
      Conserved Domains (6) summary
      PHA03247
      Location:675 → 993
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:87 → 231
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK12323
      Location:312 → 519
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:656 → 671
      PAM2; Ataxin-2 C-terminal region
      pfam06741
      Location:141 → 202
      LsmAD; LsmAD domain
      pfam14438
      Location:1 → 74
      SM-ATX; Ataxin 2 SM domain

    33. XM_030254253.2 → XP_030110113.1  ataxin-2 isoform X21

      UniProtKB/TrEMBL
      Q3UX07
      Conserved Domains (6) summary
      PHA03247
      Location:663 → 981
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:87 → 231
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK12323
      Location:300 → 482
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam06741
      Location:141 → 202
      LsmAD; LsmAD domain
      pfam07145
      Location:645 → 659
      PAM2; Ataxin-2 C-terminal region
      pfam14438
      Location:1 → 74
      SM-ATX; Ataxin 2 SM domain

    34. XM_030254256.2 → XP_030110116.1  ataxin-2 isoform X23

      UniProtKB/TrEMBL
      Q3UX07
      Conserved Domains (5) summary
      PHA03247
      Location:299 → 905
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:87 → 231
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam03154
      Location:656 → 1043
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:141 → 202
      LsmAD; LsmAD domain
      pfam14438
      Location:1 → 74
      SM-ATX; Ataxin 2 SM domain

    35. XM_030254264.2 → XP_030110124.1  ataxin-2 isoform X33

      UniProtKB/TrEMBL
      Q3UX07
      Conserved Domains (6) summary
      PHA03247
      Location:593 → 911
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:87 → 231
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK07003
      Location:267 → 436
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:574 → 589
      PAM2; Ataxin-2 C-terminal region
      pfam06741
      Location:141 → 202
      LsmAD; LsmAD domain
      pfam14438
      Location:1 → 74
      SM-ATX; Ataxin 2 SM domain

    36. XM_036164933.1 → XP_036020826.1  ataxin-2 isoform X21

      UniProtKB/TrEMBL
      Q3UX07
      Conserved Domains (6) summary
      PHA03247
      Location:663 → 981
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:87 → 231
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK12323
      Location:300 → 482
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam06741
      Location:141 → 202
      LsmAD; LsmAD domain
      pfam07145
      Location:645 → 659
      PAM2; Ataxin-2 C-terminal region
      pfam14438
      Location:1 → 74
      SM-ATX; Ataxin 2 SM domain

    37. XM_006530228.4 → XP_006530291.1  ataxin-2 isoform X15

      UniProtKB/TrEMBL
      Q3UX07
      Conserved Domains (6) summary
      PHA03247
      Location:675 → 993
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:87 → 231
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK12323
      Location:312 → 519
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:656 → 671
      PAM2; Ataxin-2 C-terminal region
      pfam06741
      Location:141 → 202
      LsmAD; LsmAD domain
      pfam14438
      Location:1 → 74
      SM-ATX; Ataxin 2 SM domain

    38. XM_030254248.2 → XP_030110108.1  ataxin-2 isoform X15

      UniProtKB/TrEMBL
      Q3UX07
      Conserved Domains (6) summary
      PHA03247
      Location:675 → 993
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:87 → 231
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK12323
      Location:312 → 519
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam07145
      Location:656 → 671
      PAM2; Ataxin-2 C-terminal region
      pfam06741
      Location:141 → 202
      LsmAD; LsmAD domain
      pfam14438
      Location:1 → 74
      SM-ATX; Ataxin 2 SM domain

    39. XM_030254254.2 → XP_030110114.1  ataxin-2 isoform X21

      UniProtKB/TrEMBL
      Q3UX07
      Conserved Domains (6) summary
      PHA03247
      Location:663 → 981
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:87 → 231
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK12323
      Location:300 → 482
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam06741
      Location:141 → 202
      LsmAD; LsmAD domain
      pfam07145
      Location:645 → 659
      PAM2; Ataxin-2 C-terminal region
      pfam14438
      Location:1 → 74
      SM-ATX; Ataxin 2 SM domain

    RNA

    1. XR_003955602.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70305.1 GenPept UniProtKB/Swiss-Prot:O70305

    Gene LinkOut

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