Rbm14 RNA binding motif protein 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbm14provided by MGI
Official Full Name: RNA binding motif protein 14provided by MGI
Primary source: MGI:MGI:1929092
See related: Ensembl:ENSMUSG00000006456 AllianceGenome:MGI:1929092
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p16; PSP2; p16K; Sytip; 1300007E16Rik
Summary: Enables mRNA binding activity and splicing factor binding activity. Involved in centriole assembly and mRNA splicing, via spliceosome. Acts upstream of or within apoptotic process; gastrulation; and regulation of response to DNA integrity checkpoint signaling. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Predicted to be active in nuclear speck. Is expressed in central nervous system; limb; liver; sensory organ; and stomach epithelium. Orthologous to several human genes including RBM14 (RNA binding motif protein 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 59.4), ovary adult (RPKM 56.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.11 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4850594..4861662, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4800566..4811634, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development.
Title: Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development.
work reveals that Rbm14 plays an essential role in the maintenance of genome integrity during early mouse embryonic development by regulating alternative splicing of DDR-related genes.
Title: Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing.
RBM14 depletion altered the gene expression profiles of mESCs. In particular, pluripotency-associated genes and genes involved in the Wnt and TGF-beta signaling pathways were downregulated in RBM14 knockout mESCs.
Title: RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rbm14 (e-PCR), detects polymorphism
- UniSTS:479222

Readthrough Gm21992

Readthrough gene: Gm21992, Included gene: Rbm4

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables splicing factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centriole assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of centriole replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of response to DNA integrity checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: RNA-binding protein 14

Names: synaptotagmin interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019869.3 → NP_063922.2 RNA-binding protein 14

See identical proteins and their annotated locations for NP_063922.2

Status: VALIDATED

Source sequence(s)

AK050945, BE956494, BM938190

Consensus CDS

CCDS29437.1

UniProtKB/Swiss-Prot

Q3TJB6, Q8C2Q3, Q91Z21, Q9DBI6

UniProtKB/TrEMBL

Q3U6A2

Related

ENSMUSP00000006625.8, ENSMUST00000006625.8

Conserved Domains (3) summary

TIGR01628
Location:3 → 280

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12608
Location:1 → 71

RRM1_CoAA; RNA recognition motif 1 in vertebrate RRM-containing coactivator activator/modulator (CoAA)

cd12609
Location:79 → 146

RRM2_CoAA; RNA recognition motif 2 in vertebrate RRM-containing coactivator activator/modulator (CoAA)