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    Abhd13 abhydrolase domain containing 13 [ Mus musculus (house mouse) ]

    Gene ID: 68904, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Abhd13provided by MGI
    Official Full Name
    abhydrolase domain containing 13provided by MGI
    Primary source
    MGI:MGI:1916154
    See related
    Ensembl:ENSMUSG00000040396 AllianceGenome:MGI:1916154
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110065L07Rik
    Summary
    Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation. Located in dendrite cytoplasm. Is expressed in metanephros. Orthologous to human ABHD13 (abhydrolase domain containing 13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 4.9), placenta adult (RPKM 4.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Abhd13 in Genome Data Viewer
    Location:
    8 A1.1; 8 4.53 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (10027717..10042155)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (9977717..9992155)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene NALCN channel auxiliary factor 1 Neighboring gene STARR-seq mESC enhancer starr_20686 Neighboring gene STARR-seq mESC enhancer starr_20687 Neighboring gene STARR-seq mESC enhancer starr_20688 Neighboring gene STARR-seq mESC enhancer starr_20691 Neighboring gene STARR-seq mESC enhancer starr_20692 Neighboring gene STARR-seq mESC enhancer starr_20693 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:9912234-9912417 Neighboring gene STARR-seq mESC enhancer starr_20694 Neighboring gene STARR-positive B cell enhancer ABC_E8225 Neighboring gene STARR-positive B cell enhancer ABC_E10489 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13b Neighboring gene ligase IV, DNA, ATP-dependent Neighboring gene predicted gene 44788

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34. Vats KR, et al. J Am Soc Nephrol, 2006 Apr. PMID 16565260
    2. Identification of PSD-95 Depalmitoylating Enzymes. Yokoi N, et al. J Neurosci, 2016 Jun 15. PMID 27307232, Free PMC Article
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein depalmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein ABHD13
    Names
    abhydrolase domain-containing protein 13
    alpha/beta hydrolase domain-containing protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081119.1 → NP_001074588.1  protein ABHD13

      See identical proteins and their annotated locations for NP_001074588.1

      Status: VALIDATED

      Description
      Transcript Variant: : This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI553397, AK032495, AK044407, BY742957
      Consensus CDS
      CCDS40217.1
      UniProtKB/Swiss-Prot
      Q80UX8, Q8BXS1, Q9D0V5
      Related
      ENSMUSP00000036730.6, ENSMUST00000048216.6
      Conserved Domains (2) summary
      pfam00561
      Location:115 → 300
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam12695
      Location:116 → 299
      Abhydrolase_5; Alpha/beta hydrolase family

    2. NM_026868.1 → NP_081144.1  protein ABHD13

      See identical proteins and their annotated locations for NP_081144.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI553397, AK032495, AK044407, BY742957, DV655120
      Consensus CDS
      CCDS40217.1
      UniProtKB/Swiss-Prot
      Q80UX8, Q8BXS1, Q9D0V5
      Related
      ENSMUSP00000116130.2, ENSMUST00000139793.8
      Conserved Domains (2) summary
      pfam00561
      Location:115 → 300
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam12695
      Location:116 → 299
      Abhydrolase_5; Alpha/beta hydrolase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      10027717..10042155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80UX8.1 GenPept UniProtKB/Swiss-Prot:Q80UX8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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