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    Glb1l2 galactosidase, beta 1-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 244757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Glb1l2provided by MGI
    Official Full Name
    galactosidase, beta 1-like 2provided by MGI
    Primary source
    MGI:MGI:2388283
    See related
    Ensembl:ENSMUSG00000036395 AllianceGenome:MGI:2388283
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable beta-galactosidase activity. Predicted to be involved in galactose catabolic process. Predicted to be located in extracellular region. Predicted to be active in vacuole. Is expressed in foregut-midgut junction; molar; nose; urinary system; and vestibulo-cochlear ganglion. Orthologous to human GLB1L2 (galactosidase beta 1 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 160.2), subcutaneous fat pad adult (RPKM 53.0) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Glb1l2 in Genome Data Viewer
    Location:
    9 A4; 9 11.56 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (26674338..26717769, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (26763044..26806473, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30313 Neighboring gene STARR-seq mESC enhancer starr_23611 Neighboring gene STARR-seq mESC enhancer starr_23613 Neighboring gene beta-1,3-glucuronyltransferase 1 Neighboring gene galactosidase, beta 1 like 3 Neighboring gene STARR-seq mESC enhancer starr_23614 Neighboring gene predicted gene 1110

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    2. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC47419

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-galactosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    beta-galactosidase-1-like protein 2
    NP_001297697.1
    NP_722498.1
    XP_006510360.1
    XP_006510361.1
    XP_006510362.1
    XP_006510363.1
    XP_006510365.1
    XP_006510366.1
    XP_036010874.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310768.1 → NP_001297697.1  beta-galactosidase-1-like protein 2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AI324066, AK033400, AK143057, BG061307, CF737161
      Consensus CDS
      CCDS80971.1
      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      UniProtKB/TrEMBL
      E0CYE1
      Related
      ENSMUSP00000066770.7, ENSMUST00000066560.13
      Conserved Domains (1) summary
      pfam01301
      Location:53 → 366
      Glyco_hydro_35; Glycosyl hydrolases family 35

    2. NM_153803.2 → NP_722498.1  beta-galactosidase-1-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_722498.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC038479, BG061307
      Consensus CDS
      CCDS40566.1
      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      UniProtKB/TrEMBL
      A0A0R4J0L1
      Related
      ENSMUSP00000047128.8, ENSMUST00000040398.14
      Conserved Domains (1) summary
      pfam01301
      Location:69 → 382
      Glyco_hydro_35; Glycosyl hydrolases family 35

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      26674338..26717769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510297.5 → XP_006510360.1  beta-galactosidase-1-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      Conserved Domains (1) summary
      pfam01301
      Location:93 → 406
      Glyco_hydro_35; Glycosyl hydrolases family 35

    2. XM_006510302.4 → XP_006510365.1  beta-galactosidase-1-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006510365.1

      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      Conserved Domains (1) summary
      pfam01301
      Location:60 → 373
      Glyco_hydro_35; Glycosyl hydrolases family 35

    3. XM_006510300.5 → XP_006510363.1  beta-galactosidase-1-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006510363.1

      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      Conserved Domains (1) summary
      pfam01301
      Location:60 → 373
      Glyco_hydro_35; Glycosyl hydrolases family 35

    4. XM_006510303.3 → XP_006510366.1  beta-galactosidase-1-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006510366.1

      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      Conserved Domains (1) summary
      pfam01301
      Location:60 → 373
      Glyco_hydro_35; Glycosyl hydrolases family 35

    5. XM_006510299.5 → XP_006510362.1  beta-galactosidase-1-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006510362.1

      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      Conserved Domains (1) summary
      pfam01301
      Location:60 → 373
      Glyco_hydro_35; Glycosyl hydrolases family 35

    6. XM_006510298.4 → XP_006510361.1  beta-galactosidase-1-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006510361.1

      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      Related
      ENSMUSP00000124415.2, ENSMUST00000162252.8
      Conserved Domains (1) summary
      pfam01301
      Location:60 → 373
      Glyco_hydro_35; Glycosyl hydrolases family 35

    7. XM_036154981.1 → XP_036010874.1  beta-galactosidase-1-like protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      Conserved Domains (1) summary
      pfam01301
      Location:60 → 373
      Glyco_hydro_35; Glycosyl hydrolases family 35
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UPY5.1 GenPept UniProtKB/Swiss-Prot:Q3UPY5

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