Cpne7 copine VII [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cpne7provided by MGI
Official Full Name: copine VIIprovided by MGI
Primary source: MGI:MGI:2142747
See related: Ensembl:ENSMUSG00000034796 AllianceGenome:MGI:2142747
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]
Expression: Biased expression in frontal lobe adult (RPKM 38.1), cortex adult (RPKM 19.5) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 72.06 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (123844054..123861924)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (123117313..123135185)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cpne7 deficiency induces cellular senescence and premature aging of dental pulp.
Title: Cpne7 deficiency induces cellular senescence and premature aging of dental pulp.
Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice.
Title: Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice.
The effect of CPNE7 on periodontal regeneration.
Title: The effect of CPNE7 on periodontal regeneration.
these results illustrate the dynamic expression of CPNE7 during tooth development and suggest its important function in entire stages of tooth development
Title: Expression of CPNE7 during mouse dentinogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to calcium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: copine-7

Names: copine 7 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_170684.2 → NP_733785.1 copine-7

See identical proteins and their annotated locations for NP_733785.1

Status: VALIDATED

Source sequence(s)

AK162900, AU079878, BF458951

Consensus CDS

CCDS22748.1

UniProtKB/Swiss-Prot

Q0VE82

Related

ENSMUSP00000042159.9, ENSMUST00000037900.9

Conserved Domains (3) summary

cd04047
Location:153 → 266

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:20 → 138

C2A_Copine; C2 domain first repeat in Copine

pfam07002
Location:325 → 542

Copine; Copine

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

123844054..123861924

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530549.2 → XP_006530612.1 copine-7 isoform X1

Conserved Domains (2) summary

cd04047
Location:30 → 143

C2B_Copine; C2 domain second repeat in Copine

pfam07002
Location:202 → 419

Copine